Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1107751..1108997 Replicon chromosome
Accession NC_012467
Organism Streptococcus pneumoniae P1031

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag SPP_RS05890 Protein ID WP_000405380.1
Coordinates 1108227..1108997 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag SPP_RS05885 Protein ID WP_000579600.1
Coordinates 1107751..1108227 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPP_RS05845 1104006..1104290 + 285 WP_000969643.1 hypothetical protein -
SPP_RS05850 1104304..1104600 + 297 WP_000998899.1 hypothetical protein -
SPP_RS05855 1104614..1104811 - 198 WP_001847545.1 hypothetical protein -
SPP_RS05860 1104971..1105612 + 642 WP_000933085.1 hypothetical protein -
SPP_RS05865 1105622..1106707 + 1086 WP_000401896.1 toprim domain-containing protein -
SPP_RS05870 1106758..1106991 + 234 WP_000152419.1 hypothetical protein -
SPP_RS05875 1106988..1107371 + 384 WP_000159221.1 hypothetical protein -
SPP_RS05880 1107409..1107681 + 273 WP_000494368.1 hypothetical protein -
SPP_RS05885 1107751..1108227 + 477 WP_000579600.1 helix-turn-helix domain-containing protein Antitoxin
SPP_RS05890 1108227..1108997 + 771 WP_000405380.1 zeta toxin family protein Toxin
SPP_RS05895 1109225..1109908 + 684 WP_000492697.1 LexA family transcriptional regulator -
SPP_RS05900 1109911..1111326 + 1416 WP_000118334.1 Y-family DNA polymerase -
SPP_RS05905 1111323..1111688 + 366 WP_000981955.1 hypothetical protein -
SPP_RS05910 1111678..1111968 + 291 WP_001080184.1 hypothetical protein -
SPP_RS05915 1112264..1112620 + 357 WP_000817506.1 hypothetical protein -
SPP_RS05920 1112625..1112990 + 366 WP_000401235.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) - 1066920..1122059 55139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29363.25 Da        Isoelectric Point: 7.1864

>T23659 WP_000405380.1 NC_012467:1108227-1108997 [Streptococcus pneumoniae P1031]
MEIQDYTDSEFKHALTRNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPRYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSKGYEVQLALIATKPELSYLSTLIRYEE
LYSINPNQARATSKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGL

Download         Length: 771 bp

>T23659 NC_012467:1108227-1108997 [Streptococcus pneumoniae P1031]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAACACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAAACTACAATTCATCGGATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACGCTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCTTTAATCGCAACCAAGCCCGAATTGTCCTATCTGAGTACTCTTATCCGATACGAAGAA
CTGTACTCTATCAATCCAAATCAAGCACGCGCAACTTCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTTGTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18257.65 Da        Isoelectric Point: 4.4899

>AT23659 WP_000579600.1 NC_012467:1107751-1108227 [Streptococcus pneumoniae P1031]
MIGKNIKSLRKTHDLTQHDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT23659 NC_012467:1107751-1108227 [Streptococcus pneumoniae P1031]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGACTTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGGTATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References