Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1958962..1959759 | Replicon | chromosome |
| Accession | NZ_CP092558 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC052 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI51_RS09670 | Protein ID | WP_000525008.1 |
| Coordinates | 1959298..1959759 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI51_RS09665 | Protein ID | WP_001260487.1 |
| Coordinates | 1958962..1959285 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI51_RS09600 (MKI51_001902) | 1954279..1954812 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI51_RS09605 (MKI51_001903) | 1954805..1955056 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI51_RS09610 (MKI51_001904) | 1955066..1955326 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI51_RS09615 (MKI51_001905) | 1955331..1955633 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI51_RS09620 (MKI51_001906) | 1955726..1955887 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI51_RS09625 (MKI51_001907) | 1955880..1956095 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI51_RS09630 (MKI51_001908) | 1956109..1956558 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI51_RS09635 (MKI51_001909) | 1956598..1956822 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI51_RS09640 (MKI51_001910) | 1956823..1957614 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI51_RS09645 (MKI51_001911) | 1957671..1957910 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI51_RS09650 (MKI51_001912) | 1957900..1958079 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI51_RS09655 (MKI51_001913) | 1958094..1958537 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI51_RS09660 (MKI51_001914) | 1958550..1958798 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI51_RS09665 (MKI51_001915) | 1958962..1959285 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI51_RS09670 (MKI51_001916) | 1959298..1959759 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI51_RS09675 (MKI51_001917) | 1959943..1960464 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI51_RS09680 (MKI51_001918) | 1960457..1960927 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI51_RS09685 (MKI51_001919) | 1960997..1962043 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI51_RS09690 (MKI51_001920) | 1962088..1963233 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI51_RS09695 (MKI51_001921) | 1963493..1964023 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1917590..1962043 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236584 WP_000525008.1 NZ_CP092558:1959298-1959759 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236584 NZ_LR698982:c52394-52029 [Gordonibacter urolithinfaciens]
ATGGGCTGGCATGTTGATATCGACTTGATCAAGCCTTGGCTCGATACCCAAGATCTCGTCACGGTTTCCTGCATAGAAGC
TGCGATCGAGGAACTTGAACGGAAGGGCCCGAGTCTCGGCAGGCCGCTGGTTGATCACATCAAGGACTCCGAGTTTTGCA
ATATGAAGGAGCTCCGTCCTGCATCGCCCGGGAGATCGGAAGTCCGCATTTTGTTTGCCTTCGATCCGAAAAGACATGCG
ATCATGCTTTTCGCCGGCGACAAATCGTCCGGAGGGAGAAGCCGCGAGAAATGGAACGGATGGTACCGATCGGCCATTCC
CTTGGCGGAAAAACGCTATCGCGAGCATCTAGGACGATTGGAGTGA
ATGGGCTGGCATGTTGATATCGACTTGATCAAGCCTTGGCTCGATACCCAAGATCTCGTCACGGTTTCCTGCATAGAAGC
TGCGATCGAGGAACTTGAACGGAAGGGCCCGAGTCTCGGCAGGCCGCTGGTTGATCACATCAAGGACTCCGAGTTTTGCA
ATATGAAGGAGCTCCGTCCTGCATCGCCCGGGAGATCGGAAGTCCGCATTTTGTTTGCCTTCGATCCGAAAAGACATGCG
ATCATGCTTTTCGCCGGCGACAAATCGTCCGGAGGGAGAAGCCGCGAGAAATGGAACGGATGGTACCGATCGGCCATTCC
CTTGGCGGAAAAACGCTATCGCGAGCATCTAGGACGATTGGAGTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236584 WP_001260487.1 NZ_CP092558:1958962-1959285 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236584 NZ_LR698982:c52025-51723 [Gordonibacter urolithinfaciens]
ATGGACATTCACGAGTATGCTATCAAGCGCGGTGTCACCCAGGAAATGCGCGATCAAGCTCGCCGTGCTACGCAGGCTAA
GGTCGATGCGTACGACCTTAGCCAGGCGCGCAAGGAGCGCGATCTGACTCAAAGTGAGGTAGCAGCCAAGATGGGCGTCT
CCCAATGCCGCGTATCGGAGCTCGAGGCCGGTCGGCTCGCCACGATGCGCGTCGATACACTGTCGCGCTACATTTCGAGC
CTTGGTGGTAAGCTCGTTATCAGCGCTGAATGGCCCGACAAGACCATCCCTTTGACCATCTAA
ATGGACATTCACGAGTATGCTATCAAGCGCGGTGTCACCCAGGAAATGCGCGATCAAGCTCGCCGTGCTACGCAGGCTAA
GGTCGATGCGTACGACCTTAGCCAGGCGCGCAAGGAGCGCGATCTGACTCAAAGTGAGGTAGCAGCCAAGATGGGCGTCT
CCCAATGCCGCGTATCGGAGCTCGAGGCCGGTCGGCTCGCCACGATGCGCGTCGATACACTGTCGCGCTACATTTCGAGC
CTTGGTGGTAAGCTCGTTATCAGCGCTGAATGGCCCGACAAGACCATCCCTTTGACCATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|