236580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848766..849243 Replicon chromosome
Accession NZ_CP092558
Organism Staphylococcus aureus strain VMRSA-WC052

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MKI51_RS04080 Protein ID WP_000052076.1
Coordinates 848766..848954 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MKI51_RS04085 Protein ID WP_001059690.1
Coordinates 848983..849243 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI51_RS04050 (MKI51_000797) 844760..845281 + 522 WP_000824482.1 hypothetical protein -
MKI51_RS04055 (MKI51_000798) 845622..846308 + 687 WP_000141557.1 thermonuclease family protein -
MKI51_RS04060 (MKI51_000799) 846665..846865 + 201 WP_001059082.1 cold-shock protein -
MKI51_RS04065 (MKI51_000800) 847357..847575 - 219 WP_000005886.1 hypothetical protein -
MKI51_RS04070 (MKI51_000801) 847637..847921 - 285 WP_001004399.1 hypothetical protein -
MKI51_RS04075 (MKI51_000802) 848009..848578 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
MKI51_RS04080 (MKI51_000803) 848766..848954 - 189 WP_000052076.1 hypothetical protein Toxin
MKI51_RS04085 (MKI51_000804) 848983..849243 - 261 WP_001059690.1 hypothetical protein Antitoxin
MKI51_RS04090 (MKI51_000805) 849584..849787 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MKI51_RS04095 (MKI51_000806) 849784..850020 - 237 WP_000349581.1 hypothetical protein -
MKI51_RS04100 (MKI51_000807) 850245..850826 + 582 WP_001140693.1 histidine phosphatase family protein -
MKI51_RS04105 (MKI51_000808) 850899..851516 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
MKI51_RS04110 (MKI51_000809) 851671..852165 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MKI51_RS04115 (MKI51_000810) 852564..852986 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MKI51_RS04120 (MKI51_000811) 853134..853850 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T236580 WP_000052076.1 NZ_CP092558:c848954-848766 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T236580 NZ_CP092558:c848954-848766 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT236580 WP_001059690.1 NZ_CP092558:c849243-848983 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT236580 NZ_CP092558:c849243-848983 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References