Detailed information of TA system TA236579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 2726402..2726921
• Replicon: chromosome
• Accession: NZ_CP092556
• Organism: Staphylococcus aureus strain VMRSA-WC062

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: MKI64_RS13675
• Protein ID: WP_000588503.1
• Coordinates: 2726664..2726921 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: MKI64_RS13670
• Protein ID: WP_000388479.1
• Coordinates: 2726402..2726671 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI64_RS13640 (MKI64_002706)	2721973..2722389	-	417	WP_001232859.1	hypothetical protein	-
MKI64_RS13645 (MKI64_002707)	2722392..2722676	-	285	WP_000353844.1	hypothetical protein	-
MKI64_RS13650 (MKI64_002708)	2723042..2723266	+	225	WP_000410576.1	hypothetical protein	-
MKI64_RS14700 (MKI64_002709)	2723568..2723654	-	87	WP_125669474.1	type I toxin-antitoxin system Fst family toxin	-
MKI64_RS13655 (MKI64_002710)	2724389..2725069	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
MKI64_RS13660 (MKI64_002711)	2725415..2725711	+	297	WP_200857964.1	hypothetical protein	-
MKI64_RS13665 (MKI64_002712)	2726092..2726271	+	180	WP_001120991.1	hypothetical protein	-
MKI64_RS13670 (MKI64_002713)	2726402..2726671	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MKI64_RS13675 (MKI64_002714)	2726664..2726921	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
MKI64_RS13680 (MKI64_002715)	2727558..2728382	+	825	WP_001809248.1	hypothetical protein	-
MKI64_RS13685 (MKI64_002716)	2728547..2729161	-	615	WP_001261742.1	recombinase family protein	-
MKI64_RS13690 (MKI64_002717)	2729611..2730936	+	1326	WP_000969590.1	Y-family DNA polymerase	-
MKI64_RS13695 (MKI64_002718)	2730929..2731279	+	351	WP_000568378.1	hypothetical protein	-
MKI64_RS13700 (MKI64_002719)	2731276..2731455	+	180	WP_001021554.1	hypothetical protein	-
MKI64_RS13705 (MKI64_002720)	2731591..2731881	+	291	WP_000026576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T236579 WP_000588503.1 NZ_CP092556:2726664-2726921 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T236579 NZ_LR698965:c2748184-2747909 [Planococcus massiliensis]
ATGTCAGCAATTACTGCAACTACACCTACCAATCTGAGAAAAGACTTATTTAATATTCTTGAAGACGTTACAGAATCTAA
CACTGAAGTAATCATTACGCTGAAGTCAGGTAAAAACGCGGTATTAATATCTGAAGATGAATTGAATGCTTATCGGGAAA
CAGCTTATTTGATGTCCACCAGAGCGAATAGAGAAAGACTTAATGACGGAATTAGTCAGTTAGAAAGTGGCAAAGGGATT
GTCCGGGATTTAATCGAAGACGATGCAGATGCTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT236579 WP_000388479.1 NZ_CP092556:2726402-2726671 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT236579 NZ_LR698965:c2747916-2747662 [Planococcus massiliensis]
ATGCTTAAAATATGGGCTGATCAAGCATGGGAGGATTATCTTTACTGGAAAGATAATGAAAAAAAGAACGTAAAAAAAAT
CAACCGACTCATCAAGGAAATCGAACGCCACCCCTTTACAGGACTGGGAAAACCGGAACCCTTGAAACATGAATGGAAGG
GTTATTGGTCCAGGCATATTACGCAAGAACATCGATTAGTTTATAAAGTTGAAAACGATTCGATATTAATTGCGCAAGCA
AGATTTCATTATTAA

Structures

Toxin

• AlphaFold DB: A0A828ZXQ8

Antitoxin

• AlphaFold DB: A0A828ZWU7