Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2103337..2103866 | Replicon | chromosome |
Accession | NZ_CP092556 | ||
Organism | Staphylococcus aureus strain VMRSA-WC062 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | MKI64_RS10445 | Protein ID | WP_000621175.1 |
Coordinates | 2103337..2103699 (-) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | T1YCG8 |
Locus tag | MKI64_RS10450 | Protein ID | WP_000948331.1 |
Coordinates | 2103696..2103866 (-) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI64_RS10425 (MKI64_002067) | 2100315..2101085 | - | 771 | WP_001041111.1 | RNA polymerase sigma factor SigB | - |
MKI64_RS10430 (MKI64_002068) | 2101060..2101539 | - | 480 | WP_001190829.1 | anti-sigma B factor RsbW | - |
MKI64_RS10435 (MKI64_002069) | 2101541..2101867 | - | 327 | WP_001052491.1 | anti-sigma factor antagonist | - |
MKI64_RS10440 (MKI64_002070) | 2101986..2102987 | - | 1002 | WP_000390829.1 | PP2C family protein-serine/threonine phosphatase | - |
MKI64_RS10445 (MKI64_002071) | 2103337..2103699 | - | 363 | WP_000621175.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MKI64_RS10450 (MKI64_002072) | 2103696..2103866 | - | 171 | WP_000948331.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
MKI64_RS10455 (MKI64_002073) | 2103951..2105099 | - | 1149 | WP_001281154.1 | alanine racemase | - |
MKI64_RS10460 (MKI64_002074) | 2105165..2105524 | - | 360 | WP_000581197.1 | holo-ACP synthase | - |
MKI64_RS10465 (MKI64_002075) | 2105528..2106019 | - | 492 | WP_001205912.1 | PH domain-containing protein | - |
MKI64_RS10470 (MKI64_002076) | 2106006..2107589 | - | 1584 | WP_001294626.1 | PH domain-containing protein | - |
MKI64_RS10475 (MKI64_002077) | 2107582..2108061 | - | 480 | WP_001287087.1 | hypothetical protein | - |
MKI64_RS10480 (MKI64_002078) | 2108269..2108829 | - | 561 | WP_001092411.1 | K(+)-transporting ATPase subunit C | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13441.69 Da Isoelectric Point: 10.1654
>T236573 WP_000621175.1 NZ_CP092556:c2103699-2103337 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
Download Length: 363 bp
>T236573 NZ_LR698955:219888-220145 [Fusobacterium nucleatum]
ATGTTATTGACTTGGACTGATTTTGCATGGGAACAATATGAAGAATTACAGGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATATCCTTATTAAGGATATAAAAAGGAATGGTAATGAAAGAATAGGAAAACCAGAACCTTTACAACATGAGCTAAGTG
GCTATTGGAGTAGAAGAATTGATTATAAAAATAGATTAGTTTATAAGATATCAGATACTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA
ATGTTATTGACTTGGACTGATTTTGCATGGGAACAATATGAAGAATTACAGGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATATCCTTATTAAGGATATAAAAAGGAATGGTAATGAAAGAATAGGAAAACCAGAACCTTTACAACATGAGCTAAGTG
GCTATTGGAGTAGAAGAATTGATTATAAAAATAGATTAGTTTATAAGATATCAGATACTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6251.78 Da Isoelectric Point: 3.8305
>AT236573 WP_000948331.1 NZ_CP092556:c2103866-2103696 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
Download Length: 171 bp
>AT236573 NZ_LR698955:219631-219888 [Fusobacterium nucleatum]
ATGATAGCAACTAATTATTCAGAGGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACAAAAGACTACGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTGATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAGGGTAATGTTAAAGAACATGAT
TTAGTAGAGGTGGATTAA
ATGATAGCAACTAATTATTCAGAGGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACAAAAGACTACGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTGATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAGGGTAATGTTAAAGAACATGAT
TTAGTAGAGGTGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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