Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1963470..1964267 Replicon chromosome
Accession NZ_CP092556
Organism Staphylococcus aureus strain VMRSA-WC062

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MKI64_RS09690 Protein ID WP_000525008.1
Coordinates 1963806..1964267 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MKI64_RS09685 Protein ID WP_001260487.1
Coordinates 1963470..1963793 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI64_RS09620 (MKI64_001908) 1958787..1959320 - 534 WP_001004326.1 host-nuclease inhibitor Gam family protein -
MKI64_RS09625 (MKI64_001909) 1959313..1959564 - 252 WP_000683290.1 hypothetical protein -
MKI64_RS09630 (MKI64_001910) 1959574..1959834 - 261 WP_000291481.1 DUF1108 family protein -
MKI64_RS09635 (MKI64_001911) 1959839..1960141 - 303 WP_000163430.1 DUF2482 family protein -
MKI64_RS09640 (MKI64_001912) 1960234..1960395 - 162 WP_000048124.1 DUF1270 family protein -
MKI64_RS09645 (MKI64_001913) 1960388..1960603 - 216 WP_000977384.1 hypothetical protein -
MKI64_RS09650 (MKI64_001914) 1960617..1961066 - 450 WP_000993183.1 hypothetical protein -
MKI64_RS09655 (MKI64_001915) 1961106..1961330 - 225 WP_000187184.1 hypothetical protein -
MKI64_RS09660 (MKI64_001916) 1961331..1962122 - 792 WP_001157019.1 phage antirepressor KilAC domain-containing protein -
MKI64_RS09665 (MKI64_001917) 1962179..1962418 + 240 WP_000438628.1 hypothetical protein -
MKI64_RS09670 (MKI64_001918) 1962408..1962587 - 180 WP_000393082.1 hypothetical protein -
MKI64_RS09675 (MKI64_001919) 1962602..1963045 - 444 WP_000435356.1 hypothetical protein -
MKI64_RS09680 (MKI64_001920) 1963058..1963306 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
MKI64_RS09685 (MKI64_001921) 1963470..1963793 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MKI64_RS09690 (MKI64_001922) 1963806..1964267 + 462 WP_000525008.1 hypothetical protein Toxin
MKI64_RS09695 (MKI64_001923) 1964451..1964972 + 522 WP_001102444.1 hypothetical protein -
MKI64_RS09700 (MKI64_001924) 1964965..1965435 + 471 WP_000183249.1 hypothetical protein -
MKI64_RS09705 (MKI64_001925) 1965505..1966551 + 1047 WP_001145732.1 tyrosine-type recombinase/integrase -
MKI64_RS09710 (MKI64_001926) 1966596..1967741 + 1146 WP_001245449.1 radical SAM/CxCxxxxC motif protein YfkAB -
MKI64_RS09715 (MKI64_001927) 1968001..1968531 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1922098..1966551 44453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18034.35 Da        Isoelectric Point: 4.6899

>T236572 WP_000525008.1 NZ_CP092556:1963806-1964267 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T236572 NZ_LR698954:c2601977-2601594 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAATAACGTTGGCAATCACTATAGTCCCACCGTCATTGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACTCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
AGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT236572 WP_001260487.1 NZ_CP092556:1963470-1963793 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT236572 NZ_LR698954:c2602245-2601997 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGTGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAGTTGATTT
CGGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References