Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1616318..1616986 Replicon chromosome
Accession NC_012466
Organism Streptococcus pneumoniae JJA

Toxin (Protein)


Gene name hicA Uniprot ID I0T4C6
Locus tag SPJ_RS08390 Protein ID WP_001132287.1
Coordinates 1616807..1616986 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPJ_RS08385 Protein ID WP_000961810.1
Coordinates 1616318..1616770 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPJ_RS08365 1613167..1614201 - 1035 WP_000747916.1 ATP-binding protein -
SPJ_RS08370 1614311..1614469 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
SPJ_RS08375 1614450..1615538 - 1089 WP_000719713.1 M50 family metallopeptidase -
SPJ_RS08380 1615557..1616027 - 471 WP_000257103.1 DUF3013 family protein -
SPJ_RS08385 1616318..1616770 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPJ_RS08390 1616807..1616986 - 180 WP_001132287.1 type II toxin-antitoxin system HicA family toxin Toxin
SPJ_RS08395 1617123..1617302 - 180 WP_001048906.1 hypothetical protein -
SPJ_RS08400 1617467..1617706 - 240 Protein_1593 hypothetical protein -
SPJ_RS08405 1617976..1619247 + 1272 WP_001113214.1 replication-associated recombination protein A -
SPJ_RS08415 1619794..1621113 - 1320 WP_000502538.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6697.91 Da        Isoelectric Point: 11.0174

>T23657 WP_001132287.1 NC_012466:c1616986-1616807 [Streptococcus pneumoniae JJA]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T23657 NC_012466:c1616986-1616807 [Streptococcus pneumoniae JJA]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT23657 WP_000961810.1 NC_012466:c1616770-1616318 [Streptococcus pneumoniae JJA]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT23657 NC_012466:c1616770-1616318 [Streptococcus pneumoniae JJA]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0T4C6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References