Detailed information of TA system TA236568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 851855..852332
• Replicon: chromosome
• Accession: NZ_CP092556
• Organism: Staphylococcus aureus strain VMRSA-WC062

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MKI64_RS04095
• Protein ID: WP_000052076.1
• Coordinates: 851855..852043 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MKI64_RS04100
• Protein ID: WP_001059690.1
• Coordinates: 852072..852332 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI64_RS04065 (MKI64_000802)	847849..848370	+	522	WP_000824482.1	hypothetical protein	-
MKI64_RS04070 (MKI64_000803)	848711..849397	+	687	WP_000141557.1	thermonuclease family protein	-
MKI64_RS04075 (MKI64_000804)	849754..849954	+	201	WP_001059082.1	cold-shock protein	-
MKI64_RS04080 (MKI64_000805)	850446..850664	-	219	WP_000005886.1	hypothetical protein	-
MKI64_RS04085 (MKI64_000806)	850726..851010	-	285	WP_001004399.1	hypothetical protein	-
MKI64_RS04090 (MKI64_000807)	851098..851667	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MKI64_RS04095 (MKI64_000808)	851855..852043	-	189	WP_000052076.1	hypothetical protein	Toxin
MKI64_RS04100 (MKI64_000809)	852072..852332	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MKI64_RS04105 (MKI64_000810)	852673..852876	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MKI64_RS04110 (MKI64_000811)	852873..853109	-	237	WP_000349581.1	hypothetical protein	-
MKI64_RS04115 (MKI64_000812)	853334..853915	+	582	WP_001140693.1	histidine phosphatase family protein	-
MKI64_RS04120 (MKI64_000813)	853988..854605	-	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
MKI64_RS04125 (MKI64_000814)	854760..855254	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MKI64_RS04130 (MKI64_000815)	855653..856075	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MKI64_RS04135 (MKI64_000816)	856223..856939	+	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	818177..862931	44754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T236568 WP_000052076.1 NZ_CP092556:c852043-851855 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T236568 NZ_LR698953:1564802-1565095 [Bifidobacterium longum]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTATTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT236568 WP_001059690.1 NZ_CP092556:c852332-852072 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT236568 NZ_LR698953:1564529-1564798 [Bifidobacterium longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATTGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGTAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56