Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2726218..2726737 Replicon chromosome
Accession NZ_CP092554
Organism Staphylococcus aureus strain VMRSA-WC071

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI61_RS13680 Protein ID WP_000588503.1
Coordinates 2726480..2726737 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI61_RS13675 Protein ID WP_000388479.1
Coordinates 2726218..2726487 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI61_RS13645 (MKI61_002709) 2721789..2722205 - 417 WP_001232859.1 hypothetical protein -
MKI61_RS13650 (MKI61_002710) 2722208..2722492 - 285 WP_000353844.1 hypothetical protein -
MKI61_RS13655 (MKI61_002711) 2722858..2723082 + 225 WP_000410576.1 hypothetical protein -
MKI61_RS14700 (MKI61_002712) 2723384..2723470 - 87 WP_125669474.1 type I toxin-antitoxin system Fst family toxin -
MKI61_RS13660 (MKI61_002713) 2724205..2724885 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI61_RS13665 2725231..2725527 + 297 WP_200857964.1 hypothetical protein -
MKI61_RS13670 (MKI61_002715) 2725908..2726087 + 180 WP_001120991.1 hypothetical protein -
MKI61_RS13675 (MKI61_002716) 2726218..2726487 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI61_RS13680 (MKI61_002717) 2726480..2726737 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI61_RS13685 (MKI61_002718) 2727374..2728198 + 825 WP_001809248.1 hypothetical protein -
MKI61_RS13690 (MKI61_002719) 2728363..2728977 - 615 WP_001261742.1 recombinase family protein -
MKI61_RS13695 (MKI61_002720) 2729427..2730752 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI61_RS13700 (MKI61_002721) 2730745..2731095 + 351 WP_000568378.1 hypothetical protein -
MKI61_RS13705 (MKI61_002722) 2731092..2731271 + 180 WP_001021554.1 hypothetical protein -
MKI61_RS13710 (MKI61_002723) 2731407..2731697 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236567 WP_000588503.1 NZ_CP092554:2726480-2726737 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236567 NZ_LR698953:1104426-1104917 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATTATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAACTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236567 WP_000388479.1 NZ_CP092554:2726218-2726487 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236567 NZ_LR698953:1104064-1104426 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGCACCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References