Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1962543..1963340 | Replicon | chromosome |
| Accession | NZ_CP092554 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC071 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI61_RS09685 | Protein ID | WP_000525008.1 |
| Coordinates | 1962879..1963340 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI61_RS09680 | Protein ID | WP_001260487.1 |
| Coordinates | 1962543..1962866 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI61_RS09615 (MKI61_001908) | 1957860..1958393 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI61_RS09620 (MKI61_001909) | 1958386..1958637 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI61_RS09625 (MKI61_001910) | 1958647..1958907 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI61_RS09630 (MKI61_001911) | 1958912..1959214 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI61_RS09635 (MKI61_001912) | 1959307..1959468 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI61_RS09640 (MKI61_001913) | 1959461..1959676 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI61_RS09645 (MKI61_001914) | 1959690..1960139 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI61_RS09650 (MKI61_001915) | 1960179..1960403 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI61_RS09655 (MKI61_001916) | 1960404..1961195 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI61_RS09660 (MKI61_001917) | 1961252..1961491 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI61_RS09665 (MKI61_001918) | 1961481..1961660 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI61_RS09670 (MKI61_001919) | 1961675..1962118 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI61_RS09675 (MKI61_001920) | 1962131..1962379 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI61_RS09680 (MKI61_001921) | 1962543..1962866 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI61_RS09685 (MKI61_001922) | 1962879..1963340 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI61_RS09690 (MKI61_001923) | 1963524..1964045 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI61_RS09695 (MKI61_001924) | 1964038..1964508 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI61_RS09700 (MKI61_001925) | 1964578..1965624 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI61_RS09705 (MKI61_001926) | 1965669..1966814 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI61_RS09710 (MKI61_001927) | 1967074..1967604 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1921171..1965624 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236560 WP_000525008.1 NZ_CP092554:1962879-1963340 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236560 NZ_LR698844:c2715043-2714702 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236560 WP_001260487.1 NZ_CP092554:1962543-1962866 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236560 NZ_LR698844:c2715273-2715043 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|