Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2723692..2724211 Replicon chromosome
Accession NZ_CP092552
Organism Staphylococcus aureus strain VMRSA-WC081

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI53_RS13635 Protein ID WP_000588503.1
Coordinates 2723954..2724211 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI53_RS13630 Protein ID WP_000388479.1
Coordinates 2723692..2723961 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI53_RS13600 (MKI53_002705) 2719263..2719679 - 417 WP_001232859.1 hypothetical protein -
MKI53_RS13605 (MKI53_002706) 2719682..2719966 - 285 WP_000353844.1 hypothetical protein -
MKI53_RS13610 (MKI53_002707) 2720332..2720556 + 225 WP_000410576.1 hypothetical protein -
MKI53_RS14635 (MKI53_002708) 2720858..2720944 - 87 WP_125669474.1 type I toxin-antitoxin system Fst family toxin -
MKI53_RS13615 (MKI53_002709) 2721679..2722359 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI53_RS13620 2722705..2723001 + 297 WP_200857964.1 hypothetical protein -
MKI53_RS13625 (MKI53_002711) 2723382..2723561 + 180 WP_001120991.1 hypothetical protein -
MKI53_RS13630 (MKI53_002712) 2723692..2723961 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI53_RS13635 (MKI53_002713) 2723954..2724211 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI53_RS13640 (MKI53_002714) 2724848..2725672 + 825 WP_001809248.1 hypothetical protein -
MKI53_RS13645 (MKI53_002715) 2725837..2726451 - 615 WP_001261742.1 recombinase family protein -
MKI53_RS13650 (MKI53_002716) 2726901..2728226 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI53_RS13655 (MKI53_002717) 2728219..2728569 + 351 WP_000568378.1 hypothetical protein -
MKI53_RS13660 (MKI53_002718) 2728566..2728745 + 180 WP_001021554.1 hypothetical protein -
MKI53_RS13665 (MKI53_002719) 2728881..2729171 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aph(3')-III / msr(A) / mph(C) / tet(S) / aac(6')-aph(2'') / VanHAX / erm(B) / ant(6)-Ia - 2616798..2749281 132483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236555 WP_000588503.1 NZ_CP092552:2723954-2724211 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236555 NZ_LR698844:c314098-314003 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236555 WP_000388479.1 NZ_CP092552:2723692-2723961 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236555 NZ_LR698844:313904-313968 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References