Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1096903..1097401 Replicon chromosome
Accession NC_012466
Organism Streptococcus pneumoniae JJA

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag SPJ_RS05660 Protein ID WP_001823540.1
Coordinates 1096903..1097157 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SPJ_RS05665 Protein ID WP_000208080.1
Coordinates 1097159..1097401 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPJ_RS05645 1092164..1094632 - 2469 WP_001152992.1 DNA gyrase subunit A -
SPJ_RS05650 1094826..1095812 + 987 WP_000204727.1 L-lactate dehydrogenase -
SPJ_RS05655 1096161..1096856 - 696 WP_000731163.1 potassium channel family protein -
SPJ_RS05660 1096903..1097157 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPJ_RS05665 1097159..1097401 - 243 WP_000208080.1 hypothetical protein Antitoxin
SPJ_RS05670 1097492..1098301 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SPJ_RS05675 1098303..1099652 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SPJ_RS05680 1099645..1100349 - 705 WP_000722076.1 response regulator transcription factor -
SPJ_RS05685 1100404..1101579 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T23655 WP_001823540.1 NC_012466:c1097157-1096903 [Streptococcus pneumoniae JJA]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T23655 NC_012466:c1097157-1096903 [Streptococcus pneumoniae JJA]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT23655 WP_000208080.1 NC_012466:c1097401-1097159 [Streptococcus pneumoniae JJA]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT23655 NC_012466:c1097401-1097159 [Streptococcus pneumoniae JJA]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References