Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 941030..942267 Replicon chromosome
Accession NC_012466
Organism Streptococcus pneumoniae JJA

Toxin (Protein)


Gene name pezT Uniprot ID C1CE39
Locus tag SPJ_RS04945 Protein ID WP_000405356.1
Coordinates 941506..942267 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A4J1TIN9
Locus tag SPJ_RS04940 Protein ID WP_000579604.1
Coordinates 941030..941506 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPJ_RS04915 936103..936957 + 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -
SPJ_RS04920 937069..937953 + 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
SPJ_RS04925 938116..939855 + 1740 WP_000423450.1 glycoside hydrolase family 13 protein -
SPJ_RS04930 939941..940258 + 318 WP_000995821.1 hypothetical protein -
SPJ_RS04935 940304..940585 + 282 WP_000266233.1 hypothetical protein -
SPJ_RS04940 941030..941506 + 477 WP_000579604.1 helix-turn-helix domain-containing protein Antitoxin
SPJ_RS04945 941506..942267 + 762 WP_000405356.1 zeta toxin family protein Toxin
SPJ_RS04950 942295..943451 + 1157 Protein_934 hypothetical protein -
SPJ_RS04960 944283..944642 + 360 WP_000529543.1 hypothetical protein -
SPJ_RS04965 944652..944981 + 330 WP_000263037.1 MobC family plasmid mobilization relaxosome protein -
SPJ_RS13055 945004..946889 + 1886 Protein_937 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 925775..953836 28061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29078.11 Da        Isoelectric Point: 7.1307

>T23654 WP_000405356.1 NC_012466:941506-942267 [Streptococcus pneumoniae JJA]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELFFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T23654 NC_012466:941506-942267 [Streptococcus pneumoniae JJA]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTATTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18271.68 Da        Isoelectric Point: 4.4969

>AT23654 WP_000579604.1 NC_012466:941030-941506 [Streptococcus pneumoniae JJA]
MIGKNIKSLRKTHDLTQHEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT23654 NC_012466:941030-941506 [Streptococcus pneumoniae JJA]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTTTCTGATTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4J1TI62

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1TIN9

References