Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1962832..1963629 | Replicon | chromosome |
| Accession | NZ_CP092550 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC082 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI63_RS09695 | Protein ID | WP_000525008.1 |
| Coordinates | 1963168..1963629 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI63_RS09690 | Protein ID | WP_001260487.1 |
| Coordinates | 1962832..1963155 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI63_RS09625 (MKI63_001907) | 1958149..1958682 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI63_RS09630 (MKI63_001908) | 1958675..1958926 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI63_RS09635 (MKI63_001909) | 1958936..1959196 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI63_RS09640 (MKI63_001910) | 1959201..1959503 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI63_RS09645 (MKI63_001911) | 1959596..1959757 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI63_RS09650 (MKI63_001912) | 1959750..1959965 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI63_RS09655 (MKI63_001913) | 1959979..1960428 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI63_RS09660 (MKI63_001914) | 1960468..1960692 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI63_RS09665 (MKI63_001915) | 1960693..1961484 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI63_RS09670 (MKI63_001916) | 1961541..1961780 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI63_RS09675 (MKI63_001917) | 1961770..1961949 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI63_RS09680 (MKI63_001918) | 1961964..1962407 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI63_RS09685 (MKI63_001919) | 1962420..1962668 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI63_RS09690 (MKI63_001920) | 1962832..1963155 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI63_RS09695 (MKI63_001921) | 1963168..1963629 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI63_RS09700 (MKI63_001922) | 1963813..1964334 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI63_RS09705 (MKI63_001923) | 1964327..1964797 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI63_RS09710 (MKI63_001924) | 1964867..1965913 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI63_RS09715 (MKI63_001925) | 1965958..1967103 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI63_RS09720 (MKI63_001926) | 1967363..1967893 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA / selk | 1814256..1965913 | 151657 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236536 WP_000525008.1 NZ_CP092550:1963168-1963629 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236536 NZ_LR595897:534807-535076 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236536 WP_001260487.1 NZ_CP092550:1962832-1963155 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236536 NZ_LR595897:535060-535344 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|