Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 71270..71789 Replicon plasmid unnamed1
Accession NZ_CP092548
Organism Staphylococcus aureus strain VMRSA-WC083

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI66_RS14495 Protein ID WP_000588503.1
Coordinates 71532..71789 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI66_RS14490 Protein ID WP_000388479.1
Coordinates 71270..71539 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI66_RS14455 (MKI66_002867) 66841..67257 - 417 WP_001232859.1 hypothetical protein -
MKI66_RS14460 (MKI66_002868) 67260..67544 - 285 WP_000353844.1 hypothetical protein -
MKI66_RS14465 (MKI66_002869) 67910..68134 + 225 WP_000410576.1 hypothetical protein -
MKI66_RS14470 (MKI66_002871) 69257..69937 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI66_RS14475 70013..70579 + 567 Protein_81 hypothetical protein -
MKI66_RS14480 70744..70944 + 201 WP_001033544.1 4-hydroxybenzoate octaprenyltransferase -
MKI66_RS14485 (MKI66_002873) 70960..71139 + 180 WP_001120991.1 hypothetical protein -
MKI66_RS14490 (MKI66_002874) 71270..71539 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI66_RS14495 (MKI66_002875) 71532..71789 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI66_RS14500 (MKI66_002876) 72426..73250 + 825 WP_001809248.1 hypothetical protein -
MKI66_RS14505 (MKI66_002877) 73415..74029 - 615 WP_001261742.1 recombinase family protein -
MKI66_RS14510 (MKI66_002878) 74479..75804 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI66_RS14515 (MKI66_002879) 75797..76147 + 351 WP_000568378.1 hypothetical protein -
MKI66_RS14520 (MKI66_002880) 76144..76323 + 180 WP_001021554.1 hypothetical protein -
MKI66_RS14525 (MKI66_002881) 76459..76749 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / tet(S) / aac(6')-aph(2'') / VanHAX - 1..78566 78566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236531 WP_000588503.1 NZ_CP092548:71532-71789 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236531 NZ_LR595857:c570987-570646 [Streptococcus sp. NCTC 11567]
ATGGCCTATAATGTACAAATTACCAAAAGTGCCGAGAGAGATCTAGACAGTATCTATCAGTTCTATCTAGATGAATTTTC
TGAACAAAGTGCTTTGAAAGTTATCAAAAGCCTTCAAGATGCTATCAGCTTTCTTTATGTTTCACCACTTGGCTACACCG
ACTTCGATTCTAAAATCAATCGAAAAATTTATCCACAAGGTAATCTAAGAATGATTCCTTCAAAGCAATACCTTATTTTT
TATCTTATCCGTGAAGAAAGGGTAGATGTTTTAAGAATTATTCATTCTAGAACAGATTATCTCAATAATTTAGAAAATCT
CTTTAAAAATCTAAACCTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236531 WP_000388479.1 NZ_CP092548:71270-71539 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236531 NZ_LR595857:c571264-570977 [Streptococcus sp. NCTC 11567]
ATGAATACACTAGCAAGAGATCGCCAATATAATTTCCGTGTCAATGCGGATATGCTAAATCAGGCTAAGGAAATTTTGGA
GGAAAAACATATGTCTCTACCTGATGCTCTTAATTTATTTGTAGAGCAAGTGGTTGTCACTAAAGACCTCCCTATCAAAA
CACCTGAGCAAGTTCAAGCTGAATCTTTCTTAAATGAATTAATTTCAGAACTTGATGAAGGCTATCAAGATGTTCTAAAA
GGAAATACAAAACCAGCTAATGAGGTTTTTGCAAAATATGGCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References