Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1962776..1963573 | Replicon | chromosome |
| Accession | NZ_CP092547 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC083 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI66_RS09705 | Protein ID | WP_000525008.1 |
| Coordinates | 1963112..1963573 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI66_RS09700 | Protein ID | WP_001260487.1 |
| Coordinates | 1962776..1963099 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI66_RS09635 (MKI66_001907) | 1958093..1958626 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI66_RS09640 (MKI66_001908) | 1958619..1958870 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI66_RS09645 (MKI66_001909) | 1958880..1959140 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI66_RS09650 (MKI66_001910) | 1959145..1959447 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI66_RS09655 (MKI66_001911) | 1959540..1959701 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI66_RS09660 (MKI66_001912) | 1959694..1959909 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI66_RS09665 (MKI66_001913) | 1959923..1960372 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI66_RS09670 (MKI66_001914) | 1960412..1960636 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI66_RS09675 (MKI66_001915) | 1960637..1961428 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI66_RS09680 (MKI66_001916) | 1961485..1961724 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI66_RS09685 (MKI66_001917) | 1961714..1961893 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI66_RS09690 (MKI66_001918) | 1961908..1962351 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI66_RS09695 (MKI66_001919) | 1962364..1962612 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI66_RS09700 (MKI66_001920) | 1962776..1963099 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI66_RS09705 (MKI66_001921) | 1963112..1963573 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI66_RS09710 (MKI66_001922) | 1963757..1964278 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI66_RS09715 (MKI66_001923) | 1964271..1964741 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI66_RS09720 (MKI66_001924) | 1964811..1965856 | + | 1046 | Protein_1879 | tyrosine-type recombinase/integrase | - |
| MKI66_RS09725 (MKI66_001925) | 1965901..1967046 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI66_RS09730 (MKI66_001926) | 1967306..1967836 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1921404..1965856 | 44452 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236524 WP_000525008.1 NZ_CP092547:1963112-1963573 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236524 NZ_LR595855:2712642-2712929 [Raoultella terrigena]
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGCTGAAGTGCTTGAGTCACCCCGAATTGAAGCGAACAAGCTTCGTGGTGTGCCTGACTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTTGGGAAA
AGAGAGCGCGCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGCTGAAGTGCTTGAGTCACCCCGAATTGAAGCGAACAAGCTTCGTGGTGTGCCTGACTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTTGGGAAA
AGAGAGCGCGCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236524 WP_001260487.1 NZ_CP092547:1962776-1963099 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236524 NZ_LR595855:2712403-2712642 [Raoultella terrigena]
ATGGGTAGCATCAACCTGCGTATTGATGATGAACTTAAAGCGCGTTCTTACGCTGCGCTCGAAAAAATGGGTGTAACTCC
CTCTGAGGCGCTTCGTCTCATGCTTGAATATATTGCTGAAAATGAACGTTTGCCGTTCAAACAGATACTCCTGAGTGATG
AAGATGCTGAGCTCGTGGAGATAGTAAAAGAGCGTCTTCGCAATCCTAAGCCAGTGCGTGTGACACTGGATGAGCTCTGA
ATGGGTAGCATCAACCTGCGTATTGATGATGAACTTAAAGCGCGTTCTTACGCTGCGCTCGAAAAAATGGGTGTAACTCC
CTCTGAGGCGCTTCGTCTCATGCTTGAATATATTGCTGAAAATGAACGTTTGCCGTTCAAACAGATACTCCTGAGTGATG
AAGATGCTGAGCTCGTGGAGATAGTAAAAGAGCGTCTTCGCAATCCTAAGCCAGTGCGTGTGACACTGGATGAGCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|