Detailed information of TA system TA023652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1784889..1785532
• Replicon: chromosome
• Accession: NC_012440
• Organism: Persephonella marina EX-H1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C0QSI5
• Locus tag: PERMA_RS09285
• Protein ID: WP_012676554.1
• Coordinates: 1785128..1785532 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: C0QSI4
• Locus tag: PERMA_RS09280
• Protein ID: WP_012676882.1
• Coordinates: 1784889..1785128 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PERMA_RS09235	1780398..1781099	+	702	WP_012676009.1	methyltransferase domain-containing protein	-
PERMA_RS09240	1781485..1781793	+	309	WP_012675749.1	hypothetical protein	-
PERMA_RS09245	1781966..1782190	+	225	WP_012676646.1	DUF433 domain-containing protein	-
PERMA_RS09250	1782635..1782844	+	210	WP_012676189.1	hypothetical protein	-
PERMA_RS09255	1782841..1783209	+	369	WP_012675399.1	type II toxin-antitoxin system VapC family toxin	-
PERMA_RS09260	1783372..1783596	+	225	WP_012675975.1	UPF0175 family protein	-
PERMA_RS09265	1783756..1783998	+	243	WP_049756074.1	DUF3368 domain-containing protein	-
PERMA_RS09270	1784053..1784286	+	234	WP_015898887.1	hypothetical protein	-
PERMA_RS09275	1784283..1784702	+	420	WP_012676107.1	PIN domain-containing protein	-
PERMA_RS09280	1784889..1785128	+	240	WP_012676882.1	antitoxin	Antitoxin
PERMA_RS09285	1785128..1785532	+	405	WP_012676554.1	type II toxin-antitoxin system VapC family toxin	Toxin
PERMA_RS09290	1785568..1785858	-	291	WP_012675577.1	hypothetical protein	-
PERMA_RS10595	1785866..1787137	-	1272	WP_012676208.1	GGDEF domain-containing protein	-
PERMA_RS09300	1787204..1787851	+	648	WP_012675373.1	methylthioribulose 1-phosphate dehydratase	-
PERMA_RS09305	1787864..1788403	+	540	WP_015898891.1	cupin domain-containing protein	-
PERMA_RS09310	1788413..1789183	+	771	WP_012675851.1	enoyl-ACP reductase	-
PERMA_RS09315	1789226..1789426	+	201	WP_012675221.1	sulfur carrier protein ThiS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15201.78 Da
• Isoelectric Point: 5.9179

>T23652 WP_012676554.1 NC_012440:1785128-1785532 [Persephonella marina EX-H1]
MIYMLDTNICSFIIRERPLTVKEKLKIIDINNNKVVLSSIVASELLYGAYKIGSPKLIDTVKTFIDFFEVLPFDLSAAEE
YGKIRSFLEKKGIVIGAYDLQIAAHARSINAILVTNNIEEFSRVEGLKIEDWTK

Nucleotide

• Length: 405 bp

>T23652 NC_012440:1785128-1785532 [Persephonella marina EX-H1]
ATGATCTATATGCTTGATACAAATATATGTAGTTTCATAATTAGAGAAAGACCTCTAACTGTAAAAGAAAAACTAAAAAT
AATTGATATAAATAATAATAAAGTTGTACTGTCAAGTATTGTTGCATCAGAACTTCTGTATGGAGCTTATAAAATAGGAA
GCCCGAAACTGATAGATACTGTAAAAACGTTCATTGATTTCTTTGAGGTTTTACCGTTCGATTTAAGTGCAGCTGAAGAA
TATGGAAAAATAAGGTCTTTTCTGGAAAAGAAAGGTATTGTTATCGGTGCTTATGACCTTCAGATAGCTGCCCACGCAAG
ATCTATAAATGCTATCCTGGTTACAAACAACATAGAAGAGTTCTCAAGAGTAGAAGGTCTAAAAATAGAAGATTGGACAA
AGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9556.99 Da
• Isoelectric Point: 5.9065

>AT23652 WP_012676882.1 NC_012440:1784889-1785128 [Persephonella marina EX-H1]
VKKTKIFKSGNSLAVRIPKGYHINAEEVYITKYDNKLVIFPEKEKWDVLFEILEELDEMERKDFLKNRNQPEPQERELF

Nucleotide

• Length: 240 bp

>AT23652 NC_012440:1784889-1785128 [Persephonella marina EX-H1]
GTGAAAAAGACAAAAATCTTTAAAAGCGGAAACTCCTTAGCGGTGAGAATACCTAAAGGCTATCATATAAATGCTGAAGA
GGTTTACATTACAAAGTATGACAATAAACTGGTCATATTCCCTGAAAAAGAGAAGTGGGATGTACTATTTGAGATATTAG
AGGAACTGGACGAGATGGAAAGGAAGGATTTTCTTAAAAACAGAAATCAGCCAGAACCTCAAGAAAGAGAGTTGTTCTAA

Structures

Toxin

• AlphaFold DB: C0QSI5

Antitoxin

• AlphaFold DB: C0QSI4