Detailed information of TA system TA023651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3474763..3475279
• Replicon: chromosome
• Accession: NC_012214
• Organism: Erwinia pyrifoliae Ep1/96

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2T7S6
• Locus tag: EPC_RS16120
• Protein ID: WP_012669379.1
• Coordinates: 3474995..3475279 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D2T7S5
• Locus tag: EPC_RS16115
• Protein ID: WP_012669378.1
• Coordinates: 3474763..3475005 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPC_RS16100	3469838..3470230	-	393	WP_012669391.1	helix-turn-helix domain-containing protein	-
EPC_RS16105	3470345..3473131	+	2787	WP_012669392.1	toprim domain-containing protein	-
EPC_RS16110	3473447..3474502	+	1056	WP_012669393.1	site-specific tyrosine recombinase XerC	-
EPC_RS16115	3474763..3475005	+	243	WP_012669378.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EPC_RS16120	3474995..3475279	+	285	WP_012669379.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EPC_RS20065	3475906..3476088	+	183	WP_081441633.1	hypothetical protein	-
EPC_RS20070	3476153..3476599	+	447	WP_012669388.1	hypothetical protein	-
EPC_RS16130	3476611..3477144	+	534	WP_012669389.1	SMI1/KNR4 family protein	-
EPC_RS16135	3477190..3477519	-	330	WP_012669390.1	type I toxin-antitoxin system SymE family toxin	-
EPC_RS16140	3477601..3477993	-	393	WP_012669391.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3442437..3484446	42009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11123.03 Da
• Isoelectric Point: 10.3769

>T23651 WP_012669379.1 NC_012214:3474995-3475279 [Erwinia pyrifoliae Ep1/96]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Nucleotide

• Length: 285 bp

>T23651 NC_012214:3474995-3475279 [Erwinia pyrifoliae Ep1/96]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9070.45 Da
• Isoelectric Point: 4.6310

>AT23651 WP_012669378.1 NC_012214:3474763-3475005 [Erwinia pyrifoliae Ep1/96]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Nucleotide

• Length: 243 bp

>AT23651 NC_012214:3474763-3475005 [Erwinia pyrifoliae Ep1/96]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Structures

Toxin

• AlphaFold DB: D2T7S6

Antitoxin

• AlphaFold DB: D2T7S5