Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 852295..852772 | Replicon | chromosome |
| Accession | NZ_CP092544 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC102 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MKI60_RS04095 | Protein ID | WP_000052076.1 |
| Coordinates | 852295..852483 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MKI60_RS04100 | Protein ID | WP_001059690.1 |
| Coordinates | 852512..852772 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI60_RS04065 (MKI60_000803) | 848289..848810 | + | 522 | WP_000824482.1 | hypothetical protein | - |
| MKI60_RS04070 (MKI60_000804) | 849151..849837 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
| MKI60_RS04075 (MKI60_000805) | 850194..850394 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MKI60_RS04080 (MKI60_000806) | 850886..851104 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| MKI60_RS04085 (MKI60_000807) | 851166..851450 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| MKI60_RS04090 (MKI60_000808) | 851538..852107 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| MKI60_RS04095 (MKI60_000809) | 852295..852483 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MKI60_RS04100 (MKI60_000810) | 852512..852772 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MKI60_RS04105 (MKI60_000811) | 853113..853316 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MKI60_RS04110 (MKI60_000812) | 853313..853549 | - | 237 | WP_000349581.1 | hypothetical protein | - |
| MKI60_RS04115 (MKI60_000813) | 853774..854355 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| MKI60_RS04120 (MKI60_000814) | 854428..855045 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| MKI60_RS04125 (MKI60_000815) | 855200..855694 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MKI60_RS04130 (MKI60_000816) | 856093..856515 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| MKI60_RS04135 (MKI60_000817) | 856663..857379 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 818616..863371 | 44755 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T236508 WP_000052076.1 NZ_CP092544:c852483-852295 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T236508 NZ_LR595691:c3060606-3060199 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT236508 WP_001059690.1 NZ_CP092544:c852772-852512 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT236508 NZ_LR595691:c3060853-3060587 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |