Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2700246..2700765 Replicon chromosome
Accession NZ_CP092542
Organism Staphylococcus aureus strain VRMSSA-WC113

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI55_RS13525 Protein ID WP_000588503.1
Coordinates 2700508..2700765 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI55_RS13520 Protein ID WP_000388479.1
Coordinates 2700246..2700515 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI55_RS13490 (MKI55_002682) 2695817..2696233 - 417 WP_001232859.1 hypothetical protein -
MKI55_RS13495 (MKI55_002683) 2696236..2696520 - 285 WP_000353844.1 hypothetical protein -
MKI55_RS13500 (MKI55_002684) 2696886..2697110 + 225 WP_000410576.1 hypothetical protein -
MKI55_RS14525 (MKI55_002685) 2697412..2697498 - 87 WP_125669474.1 type I toxin-antitoxin system Fst family toxin -
MKI55_RS13505 (MKI55_002686) 2698233..2698913 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI55_RS13510 (MKI55_002687) 2699259..2699555 + 297 WP_200857964.1 hypothetical protein -
MKI55_RS13515 (MKI55_002688) 2699936..2700115 + 180 WP_001120991.1 hypothetical protein -
MKI55_RS13520 (MKI55_002689) 2700246..2700515 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI55_RS13525 (MKI55_002690) 2700508..2700765 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI55_RS13530 (MKI55_002691) 2701402..2702226 + 825 WP_001809248.1 hypothetical protein -
MKI55_RS13535 (MKI55_002692) 2702391..2703005 - 615 WP_001261742.1 recombinase family protein -
MKI55_RS13540 (MKI55_002693) 2703455..2704780 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI55_RS13545 (MKI55_002694) 2704773..2705123 + 351 WP_000568378.1 hypothetical protein -
MKI55_RS13550 (MKI55_002695) 2705120..2705299 + 180 WP_001021554.1 hypothetical protein -
MKI55_RS13555 (MKI55_002696) 2705435..2705725 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aph(3')-III / msr(A) / mph(C) / tet(S) / aac(6')-aph(2'') / VanHAX / erm(B) / ant(6)-Ia - 2612613..2725835 113222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236507 WP_000588503.1 NZ_CP092542:2700508-2700765 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236507 NZ_LR595691:c2919015-2918680 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236507 WP_000388479.1 NZ_CP092542:2700246-2700515 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236507 NZ_LR595691:c2919263-2919015 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References