Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1936126..1936923 | Replicon | chromosome |
| Accession | NZ_CP092542 | ||
| Organism | Staphylococcus aureus strain VRMSSA-WC113 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI55_RS09540 | Protein ID | WP_000525008.1 |
| Coordinates | 1936462..1936923 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI55_RS09535 | Protein ID | WP_001260487.1 |
| Coordinates | 1936126..1936449 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI55_RS09470 (MKI55_001882) | 1931443..1931976 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI55_RS09475 (MKI55_001883) | 1931969..1932220 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI55_RS09480 (MKI55_001884) | 1932230..1932490 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI55_RS09485 (MKI55_001885) | 1932495..1932797 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI55_RS09490 (MKI55_001886) | 1932890..1933051 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI55_RS09495 (MKI55_001887) | 1933044..1933259 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI55_RS09500 (MKI55_001888) | 1933273..1933722 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI55_RS09505 (MKI55_001889) | 1933762..1933986 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI55_RS09510 (MKI55_001890) | 1933987..1934778 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI55_RS09515 (MKI55_001891) | 1934835..1935074 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI55_RS09520 (MKI55_001892) | 1935064..1935243 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI55_RS09525 (MKI55_001893) | 1935258..1935701 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI55_RS09530 (MKI55_001894) | 1935714..1935962 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI55_RS09535 (MKI55_001895) | 1936126..1936449 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI55_RS09540 (MKI55_001896) | 1936462..1936923 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI55_RS09545 (MKI55_001897) | 1937107..1937628 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI55_RS09550 (MKI55_001898) | 1937621..1938091 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI55_RS09555 (MKI55_001899) | 1938161..1939207 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI55_RS09560 (MKI55_001900) | 1939252..1940397 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI55_RS09565 (MKI55_001901) | 1940657..1941187 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1894754..1939207 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236500 WP_000525008.1 NZ_CP092542:1936462-1936923 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236500 NZ_LR595691:c1329159-1329052 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236500 WP_001260487.1 NZ_CP092542:1936126-1936449 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236500 NZ_LR595691:1329206-1329272 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|