Detailed information of TA system TA236495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 2726950..2727469
• Replicon: chromosome
• Accession: NZ_CP092540
• Organism: Staphylococcus aureus strain VMRSA-WC121

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: MKI67_RS13675
• Protein ID: WP_000588503.1
• Coordinates: 2727212..2727469 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: MKI67_RS13670
• Protein ID: WP_000388479.1
• Coordinates: 2726950..2727219 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI67_RS13640 (MKI67_002712)	2722521..2722937	-	417	WP_001232859.1	hypothetical protein	-
MKI67_RS13645 (MKI67_002713)	2722940..2723224	-	285	WP_000353844.1	hypothetical protein	-
MKI67_RS13650 (MKI67_002714)	2723590..2723814	+	225	WP_000410576.1	hypothetical protein	-
MKI67_RS14675 (MKI67_002715)	2724116..2724202	-	87	WP_125669474.1	type I toxin-antitoxin system Fst family toxin	-
MKI67_RS13655 (MKI67_002716)	2724937..2725617	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
MKI67_RS13660 (MKI67_002717)	2725963..2726259	+	297	WP_200857964.1	hypothetical protein	-
MKI67_RS13665 (MKI67_002718)	2726640..2726819	+	180	WP_001120991.1	hypothetical protein	-
MKI67_RS13670 (MKI67_002719)	2726950..2727219	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MKI67_RS13675 (MKI67_002720)	2727212..2727469	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
MKI67_RS13680 (MKI67_002721)	2728106..2728930	+	825	WP_001809248.1	hypothetical protein	-
MKI67_RS13685 (MKI67_002722)	2729095..2729709	-	615	WP_001261742.1	recombinase family protein	-
MKI67_RS13690 (MKI67_002723)	2730159..2731484	+	1326	WP_000969590.1	Y-family DNA polymerase	-
MKI67_RS13695 (MKI67_002724)	2731477..2731827	+	351	WP_000568378.1	hypothetical protein	-
MKI67_RS13700 (MKI67_002725)	2731824..2732003	+	180	WP_001021554.1	hypothetical protein	-
MKI67_RS13705 (MKI67_002726)	2732139..2732429	+	291	WP_000026576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T236495 WP_000588503.1 NZ_CP092540:2727212-2727469 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T236495 NZ_LR594692:c148436-148260 [Variovorax sp. WDL1]
ATGAAAACTTCAGAGTTCAAGCGCTTTCTCGCCTCCAAGGGGGCCAAATTTGCTGAGGGTGCAAAGCACACGAAGGTTTA
TCTCGGTGGCAGGCAATGCACGCTGCCGCGTCATAGCAAGGAGATCGGCGAGGGCTTGCGTAAGAGCATCCTGCGTCAGC
TCGAAATCAAAGATTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT236495 WP_000388479.1 NZ_CP092540:2726950-2727219 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT236495 NZ_LR594692:c148250-147834 [Variovorax sp. WDL1]
ATGTTTAGCTACCCCGCACGAGTAACGCGGGACGGCGATAGGTATATGGTGACCTTCCCGGACATTCCTGAAGCCCTGAC
TGGCGCCAAGAGCCGAGCCGAAGCCATCGAGTTGGCGGCGGATGCCTTGACGACGGCAATGGACTTCTATTTCGAGGATA
GGCGGCCCGTCCCGATGCCATCCCCTCCAAAGCGAGGGCAGATCGCAGTCGATCTTCCCCCGAGCGTTTCGGCAAAAGTA
CTGTTGCTCAATGAAATGATCGCGCAGGGCAAGCGTCCTGCTGAGTTGGCGCGGTTGATGCACGCGCGTCCGCAAGAGGT
CACCCGTCTAGTAGATCTGCACCATCCAACCAAGATCGATACCGTCGCGGCTGCGCTGCGCGCCATGGGCAAGCGCCTTG
AGCTCCGACTTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A828ZXQ8

Antitoxin

• AlphaFold DB: A0A828ZWU7