Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2123990..2124504 | Replicon | chromosome |
Accession | NZ_CP092540 | ||
Organism | Staphylococcus aureus strain VMRSA-WC121 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | T1YA99 |
Locus tag | MKI67_RS10545 | Protein ID | WP_000581792.1 |
Coordinates | 2123990..2124199 (-) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | W8UW13 |
Locus tag | MKI67_RS10550 | Protein ID | WP_000138932.1 |
Coordinates | 2124211..2124504 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI67_RS10525 (MKI67_002086) | 2119498..2120856 | - | 1359 | WP_000611464.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
MKI67_RS10530 (MKI67_002087) | 2120871..2121941 | - | 1071 | WP_000159631.1 | D-alanine--D-alanine ligase | - |
MKI67_RS10535 (MKI67_002088) | 2122259..2123461 | + | 1203 | WP_001109939.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
MKI67_RS10540 (MKI67_002089) | 2123725..2123862 | - | 138 | WP_000828354.1 | Lmo0850 family protein | - |
MKI67_RS10545 (MKI67_002090) | 2123990..2124199 | - | 210 | WP_000581792.1 | heavy metal-associated domain-containing protein | Toxin |
MKI67_RS10550 (MKI67_002091) | 2124211..2124504 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
MKI67_RS10555 (MKI67_002092) | 2124670..2126163 | + | 1494 | WP_000571554.1 | cardiolipin synthase | - |
MKI67_RS10560 (MKI67_002093) | 2126191..2126838 | + | 648 | WP_001187633.1 | HD domain-containing protein | - |
MKI67_RS10565 (MKI67_002094) | 2127751..2128623 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
MKI67_RS10570 (MKI67_002095) | 2128709..2129350 | - | 642 | WP_000483153.1 | thiamine phosphate synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T236490 WP_000581792.1 NZ_CP092540:c2124199-2123990 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T236490 NZ_LR594690:277898-278239 [Variovorax sp. WDL1]
GTGACGGGTGCGTACGTCCCTGGCCGTGGCGACGTTGTCTGGTTAGACTTCGACCCCCAAGCGGGGCATGAACAGGCGGG
TCGCCGTCCCGCGCTGGTGCTTTCACCGGCGACGTACAACGGAAAGAGCGGTTTGATGCTCTGCTGCCCGGTCACAAACC
AGGCGAAGGGCTATCCCTTCGAAGTGCCGGTCACGCCGTCCTCCGGCAAGGTCACTGGAGTTGCCTTGACTGACCAAGTG
CGATGCCTCGATTGGCGCTCTCGCAATGCCTCGAAGTTCGCTTCAGTCACGACGAAGTGCACACTGGACGTGAGCGCGAA
AGTGAAGCTTCTACTGCCCTGA
GTGACGGGTGCGTACGTCCCTGGCCGTGGCGACGTTGTCTGGTTAGACTTCGACCCCCAAGCGGGGCATGAACAGGCGGG
TCGCCGTCCCGCGCTGGTGCTTTCACCGGCGACGTACAACGGAAAGAGCGGTTTGATGCTCTGCTGCCCGGTCACAAACC
AGGCGAAGGGCTATCCCTTCGAAGTGCCGGTCACGCCGTCCTCCGGCAAGGTCACTGGAGTTGCCTTGACTGACCAAGTG
CGATGCCTCGATTGGCGCTCTCGCAATGCCTCGAAGTTCGCTTCAGTCACGACGAAGTGCACACTGGACGTGAGCGCGAA
AGTGAAGCTTCTACTGCCCTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT236490 WP_000138932.1 NZ_CP092540:c2124504-2124211 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT236490 NZ_LR594690:277668-277901 [Variovorax sp. WDL1]
ATGCGTGTTGAAGTTCAAAAGTGGGGCAACAGCGCCGCGGTGCGTGTCCCTGCTCCGGCGCTGAAAGACGCCGGTATGCA
GGTCGGCCAGAGCCTTGAGCTGCGGGTTGAAGGGGGCAAGCTGGTCATCGAGCCGGCGACAGAAAGCCTCGAAGACCTGC
TGGCGCAGATGACCCCGGAAAACCAGCATGGTTTGGCACTGGAAGGGCCGGCGGTAGGGGCTGAGGCTTGGTGA
ATGCGTGTTGAAGTTCAAAAGTGGGGCAACAGCGCCGCGGTGCGTGTCCCTGCTCCGGCGCTGAAAGACGCCGGTATGCA
GGTCGGCCAGAGCCTTGAGCTGCGGGTTGAAGGGGGCAAGCTGGTCATCGAGCCGGCGACAGAAAGCCTCGAAGACCTGC
TGGCGCAGATGACCCCGGAAAACCAGCATGGTTTGGCACTGGAAGGGCCGGCGGTAGGGGCTGAGGCTTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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