Detailed information of TA system TA023649

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3233103..3233763
• Replicon: chromosome
• Accession: NC_012214
• Organism: Erwinia pyrifoliae Ep1/96

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D2T6A5
• Locus tag: EPC_RS14955
• Protein ID: WP_014539414.1
• Coordinates: 3233103..3233516 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: EPC_RS14960
• Protein ID: WP_012669171.1
• Coordinates: 3233497..3233763 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPC_RS14935	3229543..3230247	-	705	WP_012669166.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EPC_RS14940	3230293..3231186	-	894	WP_014543356.1	site-specific tyrosine recombinase XerD	-
EPC_RS14945	3231462..3232415	+	954	WP_012669168.1	DMT family transporter	-
EPC_RS14950	3232461..3232979	+	519	WP_012669169.1	flavodoxin FldB	-
EPC_RS14955	3233103..3233516	-	414	WP_014539414.1	hypothetical protein	Toxin
EPC_RS14960	3233497..3233763	-	267	WP_012669171.1	FAD assembly factor SdhE	Antitoxin
EPC_RS14965	3233989..3234975	+	987	WP_012669172.1	tRNA-modifying protein YgfZ	-
EPC_RS14970	3234976..3235635	-	660	WP_012669173.1	hemolysin III family protein	-
EPC_RS14975	3235848..3236456	+	609	WP_012669174.1	HD domain-containing protein	-
EPC_RS19565	3236550..3236678	-	129	Protein_2875	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16057.13 Da
• Isoelectric Point: 12.3470

>T23649 WP_014539414.1 NC_012214:c3233516-3233103 [Erwinia pyrifoliae Ep1/96]
VVLWQCELRQSKLAQRLSLLLHGAVMLALLLPAWPASAGLVRMLLLVLVLLECIRSRRRIRRRQGDVALLGGHALRWRQR
EWRILSRPWLTRQAILLSLRDAKGERERLWLFADGMADSHWRRLRMQLLNNKEQGNG

Nucleotide

• Length: 414 bp

>T23649 NC_012214:c3233516-3233103 [Erwinia pyrifoliae Ep1/96]
GTGGTCCTGTGGCAATGTGAACTGCGTCAGTCAAAGCTGGCACAGCGGCTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTACTGCCTGCATGGCCCGCCAGCGCTGGCCTGGTACGGATGCTGTTGCTGGTTTTGGTACTGCTGGAGTGCA
TACGCAGCCGGCGGCGCATCCGCCGCCGCCAGGGTGATGTCGCCCTGTTGGGCGGACATGCGCTACGCTGGCGGCAGCGC
GAGTGGCGCATCCTTTCCCGCCCGTGGCTTACCCGGCAGGCGATCCTGCTGTCACTGCGTGATGCCAAAGGGGAGCGTGA
ACGGCTGTGGCTGTTCGCCGACGGCATGGCAGACAGTCACTGGCGTCGGTTACGTATGCAGTTGCTGAACAATAAGGAGC
AGGGGAATGGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10482.07 Da
• Isoelectric Point: 6.4605

>AT23649 WP_012669171.1 NC_012214:c3233763-3233497 [Erwinia pyrifoliae Ep1/96]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDGDKRLFVRLLESDDPDLFNWLMNHGEPADAELKRMVLLIQQRN
KQRGPVAM

Nucleotide

• Length: 267 bp

>AT23649 NC_012214:c3233763-3233497 [Erwinia pyrifoliae Ep1/96]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTGGATATCTCGATCATGCCGTT
TTTTCAGTACGAATTTGACTCGCTGAACGATGGCGATAAGCGTCTGTTTGTCCGCCTGTTAGAGAGCGACGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGAGAGCCGGCAGATGCGGAGCTGAAAAGGATGGTGTTGCTTATCCAGCAGAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: D2T6A5