Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1962862..1963659 Replicon chromosome
Accession NZ_CP092540
Organism Staphylococcus aureus strain VMRSA-WC121

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MKI67_RS09690 Protein ID WP_000525008.1
Coordinates 1963198..1963659 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MKI67_RS09685 Protein ID WP_001260487.1
Coordinates 1962862..1963185 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI67_RS09620 (MKI67_001908) 1958179..1958712 - 534 WP_001004326.1 host-nuclease inhibitor Gam family protein -
MKI67_RS09625 (MKI67_001909) 1958705..1958956 - 252 WP_000683290.1 hypothetical protein -
MKI67_RS09630 (MKI67_001910) 1958966..1959226 - 261 WP_000291481.1 DUF1108 family protein -
MKI67_RS09635 (MKI67_001911) 1959231..1959533 - 303 WP_000163430.1 DUF2482 family protein -
MKI67_RS09640 (MKI67_001912) 1959626..1959787 - 162 WP_000048124.1 DUF1270 family protein -
MKI67_RS09645 (MKI67_001913) 1959780..1959995 - 216 WP_000977384.1 hypothetical protein -
MKI67_RS09650 (MKI67_001914) 1960009..1960458 - 450 WP_000993183.1 hypothetical protein -
MKI67_RS09655 (MKI67_001915) 1960498..1960722 - 225 WP_000187184.1 hypothetical protein -
MKI67_RS09660 (MKI67_001916) 1960723..1961514 - 792 WP_001157019.1 phage antirepressor KilAC domain-containing protein -
MKI67_RS09665 (MKI67_001917) 1961571..1961810 + 240 WP_000438628.1 hypothetical protein -
MKI67_RS09670 (MKI67_001918) 1961800..1961979 - 180 WP_000393082.1 hypothetical protein -
MKI67_RS09675 (MKI67_001919) 1961994..1962437 - 444 WP_000435356.1 hypothetical protein -
MKI67_RS09680 (MKI67_001920) 1962450..1962698 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
MKI67_RS09685 (MKI67_001921) 1962862..1963185 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MKI67_RS09690 (MKI67_001922) 1963198..1963659 + 462 WP_000525008.1 hypothetical protein Toxin
MKI67_RS09695 (MKI67_001923) 1963843..1964364 + 522 WP_001102444.1 hypothetical protein -
MKI67_RS09700 (MKI67_001924) 1964357..1964827 + 471 WP_000183249.1 hypothetical protein -
MKI67_RS09705 (MKI67_001925) 1964897..1965943 + 1047 WP_001145732.1 tyrosine-type recombinase/integrase -
MKI67_RS09710 (MKI67_001926) 1965988..1967133 + 1146 WP_001245449.1 radical SAM/CxCxxxxC motif protein YfkAB -
MKI67_RS09715 (MKI67_001927) 1967393..1967923 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1921489..1965943 44454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18034.35 Da        Isoelectric Point: 4.6899

>T236488 WP_000525008.1 NZ_CP092540:1963198-1963659 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T236488 NZ_LR594689:c5420126-5419755 [Variovorax sp. WDL1]
ATGATCCTCGTTGACACGTCGGTGTGGATAGACCACCTCGCCCGAGGCGATTCAGGACTGCAATCGCTGCTGGAGGAAGG
TGAAGTCCTCATGCACCCGTACATCGTCGCGGAAATTGCTCTGGGCAGCCTGACCAGGCGGGACGAGACGGTCGGCGCGT
TGCAAGCCTTGCCCGAGGTCACGGTAGCGCGCCACGTCGAGGTGATGGCGTTTCTTGGCAACGAGCGGCTGTTCGGCATC
GGGATCGGCTATGTCGATCTTCACCTGCTCGCCGCGACTCGCCTCGCTGCAGGTACGAAGCTTTGGACGCGCGATCGACG
CCTTCTCCAGGCCGCACTCAGGCTGGATCTGGCCCGGTTCCCTGCACATTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT236488 WP_001260487.1 NZ_CP092540:1962862-1963185 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT236488 NZ_LR594689:c5420322-5420113 [Variovorax sp. WDL1]
ATGCGCACCACCGTGACCCTGGACGACGAGTTGCTCTCTCAAGCTCGAGCATTCACGGGCATCCAGGAGAACTCCGCGCT
GCTTCAACAAGCGCTCAAGGCGCTCGTCCAGAGGGAAGCCGCGCGTCGGCTGGCGCGCTTGGGAGGCAGTGCGCCGGGCC
TTCGCCCAGCGCCACGACGCCGTGGGAAAGTCGCAGATGATCCTCGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References