Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 852282..852759 Replicon chromosome
Accession NZ_CP092540
Organism Staphylococcus aureus strain VMRSA-WC121

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MKI67_RS04100 Protein ID WP_000052076.1
Coordinates 852282..852470 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MKI67_RS04105 Protein ID WP_001059690.1
Coordinates 852499..852759 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI67_RS04070 (MKI67_000803) 848276..848797 + 522 WP_000824482.1 hypothetical protein -
MKI67_RS04075 (MKI67_000804) 849138..849824 + 687 WP_000141557.1 thermonuclease family protein -
MKI67_RS04080 (MKI67_000805) 850181..850381 + 201 WP_001059082.1 cold-shock protein -
MKI67_RS04085 (MKI67_000806) 850873..851091 - 219 WP_000005886.1 hypothetical protein -
MKI67_RS04090 (MKI67_000807) 851153..851437 - 285 WP_001004399.1 hypothetical protein -
MKI67_RS04095 (MKI67_000808) 851525..852094 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
MKI67_RS04100 (MKI67_000809) 852282..852470 - 189 WP_000052076.1 hypothetical protein Toxin
MKI67_RS04105 (MKI67_000810) 852499..852759 - 261 WP_001059690.1 hypothetical protein Antitoxin
MKI67_RS04110 (MKI67_000811) 853100..853303 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MKI67_RS04115 (MKI67_000812) 853300..853536 - 237 WP_000349581.1 hypothetical protein -
MKI67_RS04120 (MKI67_000813) 853761..854342 + 582 WP_001140693.1 histidine phosphatase family protein -
MKI67_RS04125 (MKI67_000814) 854415..855032 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
MKI67_RS04130 (MKI67_000815) 855187..855681 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MKI67_RS04135 (MKI67_000816) 856080..856502 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MKI67_RS04140 (MKI67_000817) 856650..857366 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 818604..863358 44754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T236484 WP_000052076.1 NZ_CP092540:c852470-852282 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T236484 NZ_LR594689:1403812-1405161 [Variovorax sp. WDL1]
ATGGGTCGACGTTCTCACACCCAGGCGCTCGCCCTCTGGATGAACGGCGCACGCGTAGGTACCTGGCGCATCCATCCGCA
GGCAGGCGACGTCCTCGAGTACAGCCCGGATTGGACTGCTTCAGAGCAGGGCCGGCCTCTGTCACTGTCCCTTCCCTTCA
TGCCGGGAGGCGCCCCGCACCGCGGCGAAAGGGTTCGAACCTACTTCGAAAATCTGCTGCCCGACAGCGACGACATCCGC
GCGAGGATCGCTCGGCGCTACCAGACCAAGTCGACCGATGCCTTCCCGCTGCTCGCCGAGATTGGACGCGACTGCGTGGG
CGCGTTGCAGATTCTTCCGGACGGCGAAGTCCCGGCAGGCGTGCAGCCAGTGCAAGCCTCGCCCTTGAATGAGAGCATGG
TCGCGCAGGTGTTGCGCAACACCGTGTCGCCCACCCTCGTGAGTCTTGGCGACGATGACGACACCTTCCGCATTTCGATC
GCAGGCGCGCAGGAGAAAACCGCGCTGCTGCGCTTCGAAGGCAAATGGTGCATGCCGCATGGGGACACGCCGACGACACA
CATCTTCAAGCTCCCTCTGGGCCTGATCGGCGGGATGAAGTACGACATGAGCGACTCTGTCGAAAACGAGTGGCTATGTT
CCTTGATCCTGAAGGCCTACGGCCTGCCGGTGGCCGCCTGCGAGCCGCTGCAGTTCGAGGACGTCAAGGTTCTGGCGGTG
GAGCGCTTCGACCGCAGCTGGTGGAAAAGCCCGGCGGGCGACATGCGGCTCATCCGACTTCCTCAGGAGGATATGTGCCA
GGCCAAGGGCGTATCCCCGCACGCGAAGTACGAAGCCGACGGCGGCCCTGGCATTGACAGCATCATGGATGTGCTCGAGG
GGTCCCTGTCCCGCCAAGATGACAAACGGGCCTTCTTCCAGGCGCAATTGGTCTTCTGGCTGCTGTGCGCGACCGATGGC
CACGCGAAGAACTTCAGCTTGTTCCTGCGCCCCGGAGGCCGATACCAGCTCACGCCGCTGTACGACGTGCTGTCGGCCTA
CCCTGTCCTCGGCGAAGGCCCGGGGAAGCTGTCGCCGTTCAAGGCCAGGATGGCCATGGCGATCCGCTCCAGGAACGCCC
ACTGGAAGATGCGCGACATCCTGCGCCGGCACTGGCTGGTCATGGGCGAGCGTCATGGGGTGACCACCCCCGACGGACGC
GATGTGCGTTTCGTCATCGACGATCTCGCGGACCGCACGCCCAAGGTGATTCGACAGGTGCGAGCGAAGTTGCCGAAGGA
CTTTCCAGAGCCCTTGGTCGAAGCCATCCTCGGTGGGCTTCAGGAAGCCGCCAACAAGATCTCGGACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT236484 WP_001059690.1 NZ_CP092540:c852759-852499 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT236484 NZ_LR594689:1403536-1403808 [Variovorax sp. WDL1]
ATGCCTGAGTTTGTTCTCCGCACCTCCGAGCAGTTGCCCGGCCTGCTCCAGGCGTTTCGCAAGCAAACCGGCATGACCCA
GGCCGAGGCCGCCGTCCGCCTGGGGGTGACCCAGCAGACGATGTCCGCATTGGAGCGCAACGCGGAGAAGGTCAGCGCCG
CCCGGCTGATGAAGCTGCTGAGCATCCTGGGCGTCGAGCTGGTGCTGCGAAAGGACGACGCAATGGCGCCCCCGAAGTCG
GCCAGCGCCACCGACTCGAATCCGACTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References