Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 852282..852759 | Replicon | chromosome |
Accession | NZ_CP092540 | ||
Organism | Staphylococcus aureus strain VMRSA-WC121 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | MKI67_RS04100 | Protein ID | WP_000052076.1 |
Coordinates | 852282..852470 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | MKI67_RS04105 | Protein ID | WP_001059690.1 |
Coordinates | 852499..852759 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI67_RS04070 (MKI67_000803) | 848276..848797 | + | 522 | WP_000824482.1 | hypothetical protein | - |
MKI67_RS04075 (MKI67_000804) | 849138..849824 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
MKI67_RS04080 (MKI67_000805) | 850181..850381 | + | 201 | WP_001059082.1 | cold-shock protein | - |
MKI67_RS04085 (MKI67_000806) | 850873..851091 | - | 219 | WP_000005886.1 | hypothetical protein | - |
MKI67_RS04090 (MKI67_000807) | 851153..851437 | - | 285 | WP_001004399.1 | hypothetical protein | - |
MKI67_RS04095 (MKI67_000808) | 851525..852094 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
MKI67_RS04100 (MKI67_000809) | 852282..852470 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
MKI67_RS04105 (MKI67_000810) | 852499..852759 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
MKI67_RS04110 (MKI67_000811) | 853100..853303 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
MKI67_RS04115 (MKI67_000812) | 853300..853536 | - | 237 | WP_000349581.1 | hypothetical protein | - |
MKI67_RS04120 (MKI67_000813) | 853761..854342 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
MKI67_RS04125 (MKI67_000814) | 854415..855032 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
MKI67_RS04130 (MKI67_000815) | 855187..855681 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
MKI67_RS04135 (MKI67_000816) | 856080..856502 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
MKI67_RS04140 (MKI67_000817) | 856650..857366 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | vWbp | 818604..863358 | 44754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T236484 WP_000052076.1 NZ_CP092540:c852470-852282 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T236484 NZ_LR594689:1403812-1405161 [Variovorax sp. WDL1]
ATGGGTCGACGTTCTCACACCCAGGCGCTCGCCCTCTGGATGAACGGCGCACGCGTAGGTACCTGGCGCATCCATCCGCA
GGCAGGCGACGTCCTCGAGTACAGCCCGGATTGGACTGCTTCAGAGCAGGGCCGGCCTCTGTCACTGTCCCTTCCCTTCA
TGCCGGGAGGCGCCCCGCACCGCGGCGAAAGGGTTCGAACCTACTTCGAAAATCTGCTGCCCGACAGCGACGACATCCGC
GCGAGGATCGCTCGGCGCTACCAGACCAAGTCGACCGATGCCTTCCCGCTGCTCGCCGAGATTGGACGCGACTGCGTGGG
CGCGTTGCAGATTCTTCCGGACGGCGAAGTCCCGGCAGGCGTGCAGCCAGTGCAAGCCTCGCCCTTGAATGAGAGCATGG
TCGCGCAGGTGTTGCGCAACACCGTGTCGCCCACCCTCGTGAGTCTTGGCGACGATGACGACACCTTCCGCATTTCGATC
GCAGGCGCGCAGGAGAAAACCGCGCTGCTGCGCTTCGAAGGCAAATGGTGCATGCCGCATGGGGACACGCCGACGACACA
CATCTTCAAGCTCCCTCTGGGCCTGATCGGCGGGATGAAGTACGACATGAGCGACTCTGTCGAAAACGAGTGGCTATGTT
CCTTGATCCTGAAGGCCTACGGCCTGCCGGTGGCCGCCTGCGAGCCGCTGCAGTTCGAGGACGTCAAGGTTCTGGCGGTG
GAGCGCTTCGACCGCAGCTGGTGGAAAAGCCCGGCGGGCGACATGCGGCTCATCCGACTTCCTCAGGAGGATATGTGCCA
GGCCAAGGGCGTATCCCCGCACGCGAAGTACGAAGCCGACGGCGGCCCTGGCATTGACAGCATCATGGATGTGCTCGAGG
GGTCCCTGTCCCGCCAAGATGACAAACGGGCCTTCTTCCAGGCGCAATTGGTCTTCTGGCTGCTGTGCGCGACCGATGGC
CACGCGAAGAACTTCAGCTTGTTCCTGCGCCCCGGAGGCCGATACCAGCTCACGCCGCTGTACGACGTGCTGTCGGCCTA
CCCTGTCCTCGGCGAAGGCCCGGGGAAGCTGTCGCCGTTCAAGGCCAGGATGGCCATGGCGATCCGCTCCAGGAACGCCC
ACTGGAAGATGCGCGACATCCTGCGCCGGCACTGGCTGGTCATGGGCGAGCGTCATGGGGTGACCACCCCCGACGGACGC
GATGTGCGTTTCGTCATCGACGATCTCGCGGACCGCACGCCCAAGGTGATTCGACAGGTGCGAGCGAAGTTGCCGAAGGA
CTTTCCAGAGCCCTTGGTCGAAGCCATCCTCGGTGGGCTTCAGGAAGCCGCCAACAAGATCTCGGACTGA
ATGGGTCGACGTTCTCACACCCAGGCGCTCGCCCTCTGGATGAACGGCGCACGCGTAGGTACCTGGCGCATCCATCCGCA
GGCAGGCGACGTCCTCGAGTACAGCCCGGATTGGACTGCTTCAGAGCAGGGCCGGCCTCTGTCACTGTCCCTTCCCTTCA
TGCCGGGAGGCGCCCCGCACCGCGGCGAAAGGGTTCGAACCTACTTCGAAAATCTGCTGCCCGACAGCGACGACATCCGC
GCGAGGATCGCTCGGCGCTACCAGACCAAGTCGACCGATGCCTTCCCGCTGCTCGCCGAGATTGGACGCGACTGCGTGGG
CGCGTTGCAGATTCTTCCGGACGGCGAAGTCCCGGCAGGCGTGCAGCCAGTGCAAGCCTCGCCCTTGAATGAGAGCATGG
TCGCGCAGGTGTTGCGCAACACCGTGTCGCCCACCCTCGTGAGTCTTGGCGACGATGACGACACCTTCCGCATTTCGATC
GCAGGCGCGCAGGAGAAAACCGCGCTGCTGCGCTTCGAAGGCAAATGGTGCATGCCGCATGGGGACACGCCGACGACACA
CATCTTCAAGCTCCCTCTGGGCCTGATCGGCGGGATGAAGTACGACATGAGCGACTCTGTCGAAAACGAGTGGCTATGTT
CCTTGATCCTGAAGGCCTACGGCCTGCCGGTGGCCGCCTGCGAGCCGCTGCAGTTCGAGGACGTCAAGGTTCTGGCGGTG
GAGCGCTTCGACCGCAGCTGGTGGAAAAGCCCGGCGGGCGACATGCGGCTCATCCGACTTCCTCAGGAGGATATGTGCCA
GGCCAAGGGCGTATCCCCGCACGCGAAGTACGAAGCCGACGGCGGCCCTGGCATTGACAGCATCATGGATGTGCTCGAGG
GGTCCCTGTCCCGCCAAGATGACAAACGGGCCTTCTTCCAGGCGCAATTGGTCTTCTGGCTGCTGTGCGCGACCGATGGC
CACGCGAAGAACTTCAGCTTGTTCCTGCGCCCCGGAGGCCGATACCAGCTCACGCCGCTGTACGACGTGCTGTCGGCCTA
CCCTGTCCTCGGCGAAGGCCCGGGGAAGCTGTCGCCGTTCAAGGCCAGGATGGCCATGGCGATCCGCTCCAGGAACGCCC
ACTGGAAGATGCGCGACATCCTGCGCCGGCACTGGCTGGTCATGGGCGAGCGTCATGGGGTGACCACCCCCGACGGACGC
GATGTGCGTTTCGTCATCGACGATCTCGCGGACCGCACGCCCAAGGTGATTCGACAGGTGCGAGCGAAGTTGCCGAAGGA
CTTTCCAGAGCCCTTGGTCGAAGCCATCCTCGGTGGGCTTCAGGAAGCCGCCAACAAGATCTCGGACTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT236484 WP_001059690.1 NZ_CP092540:c852759-852499 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT236484 NZ_LR594689:1403536-1403808 [Variovorax sp. WDL1]
ATGCCTGAGTTTGTTCTCCGCACCTCCGAGCAGTTGCCCGGCCTGCTCCAGGCGTTTCGCAAGCAAACCGGCATGACCCA
GGCCGAGGCCGCCGTCCGCCTGGGGGTGACCCAGCAGACGATGTCCGCATTGGAGCGCAACGCGGAGAAGGTCAGCGCCG
CCCGGCTGATGAAGCTGCTGAGCATCCTGGGCGTCGAGCTGGTGCTGCGAAAGGACGACGCAATGGCGCCCCCGAAGTCG
GCCAGCGCCACCGACTCGAATCCGACTTGGTAA
ATGCCTGAGTTTGTTCTCCGCACCTCCGAGCAGTTGCCCGGCCTGCTCCAGGCGTTTCGCAAGCAAACCGGCATGACCCA
GGCCGAGGCCGCCGTCCGCCTGGGGGTGACCCAGCAGACGATGTCCGCATTGGAGCGCAACGCGGAGAAGGTCAGCGCCG
CCCGGCTGATGAAGCTGCTGAGCATCCTGGGCGTCGAGCTGGTGCTGCGAAAGGACGACGCAATGGCGCCCCCGAAGTCG
GCCAGCGCCACCGACTCGAATCCGACTTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |