Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2726510..2727029 Replicon chromosome
Accession NZ_CP092538
Organism Staphylococcus aureus strain VMRSA-WC123

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI57_RS13680 Protein ID WP_000588503.1
Coordinates 2726772..2727029 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI57_RS13675 Protein ID WP_000388479.1
Coordinates 2726510..2726779 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI57_RS13645 (MKI57_002709) 2722081..2722497 - 417 WP_001232859.1 hypothetical protein -
MKI57_RS13650 (MKI57_002710) 2722500..2722784 - 285 WP_000353844.1 hypothetical protein -
MKI57_RS13655 (MKI57_002711) 2723150..2723374 + 225 WP_000410576.1 hypothetical protein -
MKI57_RS14700 (MKI57_002712) 2723676..2723762 - 87 WP_125669474.1 type I toxin-antitoxin system Fst family toxin -
MKI57_RS13660 (MKI57_002713) 2724497..2725177 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI57_RS13665 2725523..2725819 + 297 WP_200857964.1 hypothetical protein -
MKI57_RS13670 (MKI57_002715) 2726200..2726379 + 180 WP_001120991.1 hypothetical protein -
MKI57_RS13675 (MKI57_002716) 2726510..2726779 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI57_RS13680 (MKI57_002717) 2726772..2727029 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI57_RS13685 (MKI57_002718) 2727666..2728490 + 825 WP_001809248.1 hypothetical protein -
MKI57_RS13690 (MKI57_002719) 2728655..2729269 - 615 WP_001261742.1 recombinase family protein -
MKI57_RS13695 (MKI57_002720) 2729719..2731044 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI57_RS13700 (MKI57_002721) 2731037..2731387 + 351 WP_000568378.1 hypothetical protein -
MKI57_RS13705 (MKI57_002722) 2731384..2731563 + 180 WP_001021554.1 hypothetical protein -
MKI57_RS13710 (MKI57_002723) 2731699..2731989 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236483 WP_000588503.1 NZ_CP092538:2726772-2727029 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236483 NZ_LR594689:609824-610276 [Variovorax sp. WDL1]
ATGAGCGCCGAAGCCGCAACGAACTCGTTGCGCCTGCTGGATACGAACACCGTCTTCGAGTTGATGCGCCACCCAGGGGG
CAAGGTTGCCGCGCGACTCCGACGCCTGGCGCAAGAACAGCCTGACGGCAGAGTCTGCACCAGCGCCGTGGTGGACTGCG
AGTTGCGATTCGGTGTGAACCGCAAAGGATCGGCACGACTGGCCGATGCGTACACCCGCGCCATGTCCGTCATCGAAGTT
CGCGACCTGCCTGCTGCAGTCGCTCCGATCTACGCAGACATTCGCACCCAGCTCGAACAGGTTGGCAAGCCGATCGGCCC
CAACGATCTGCTGATTGCCGCCCATGCGCTGGCACTGGACGCAACGCTGGTGACCCACAACGAAAGTGAATTCCGGCGCG
TGCCCGGACTTGTCGTCGAAAACTGGCTGGAATCAGCCCATGAACATGAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236483 WP_000388479.1 NZ_CP092538:2726510-2726779 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236483 NZ_LR594689:609555-609827 [Variovorax sp. WDL1]
ATGTCTGACCCCCACCTTCCTGCCCGCAGTGTCCGGCTGTTTCGCAATGGCGCAAACCAGGCTGTGCGCATCCCGCGCGA
GTTCGAGCTTCCGGGAAACGAGGCGCTGATGCGACGCGACGGTGACACCCTGGTGATCGAGCCCGTGTACCCTGTGCCCC
GCAAAGGCACCCTGGCCGGCTTGGCCGCGGTGCTGGCGACGATGGAACCGCTGGACGAAGAATTCCCCGATGTAGACAAA
GGTCTGCTGCCCCTGGACGACGTCGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References