Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1962453..1963250 Replicon chromosome
Accession NZ_CP092538
Organism Staphylococcus aureus strain VMRSA-WC123

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MKI57_RS09685 Protein ID WP_000525008.1
Coordinates 1962789..1963250 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MKI57_RS09680 Protein ID WP_001260487.1
Coordinates 1962453..1962776 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI57_RS09615 (MKI57_001907) 1957770..1958303 - 534 WP_001004326.1 host-nuclease inhibitor Gam family protein -
MKI57_RS09620 (MKI57_001908) 1958296..1958547 - 252 WP_000683290.1 hypothetical protein -
MKI57_RS09625 (MKI57_001909) 1958557..1958817 - 261 WP_000291481.1 DUF1108 family protein -
MKI57_RS09630 (MKI57_001910) 1958822..1959124 - 303 WP_000163430.1 DUF2482 family protein -
MKI57_RS09635 (MKI57_001911) 1959217..1959378 - 162 WP_000048124.1 DUF1270 family protein -
MKI57_RS09640 (MKI57_001912) 1959371..1959586 - 216 WP_000977384.1 hypothetical protein -
MKI57_RS09645 (MKI57_001913) 1959600..1960049 - 450 WP_000993183.1 hypothetical protein -
MKI57_RS09650 (MKI57_001914) 1960089..1960313 - 225 WP_000187184.1 hypothetical protein -
MKI57_RS09655 (MKI57_001915) 1960314..1961105 - 792 WP_001157019.1 phage antirepressor KilAC domain-containing protein -
MKI57_RS09660 (MKI57_001916) 1961162..1961401 + 240 WP_000438628.1 hypothetical protein -
MKI57_RS09665 (MKI57_001917) 1961391..1961570 - 180 WP_000393082.1 hypothetical protein -
MKI57_RS09670 (MKI57_001918) 1961585..1962028 - 444 WP_000435356.1 hypothetical protein -
MKI57_RS09675 (MKI57_001919) 1962041..1962289 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
MKI57_RS09680 (MKI57_001920) 1962453..1962776 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MKI57_RS09685 (MKI57_001921) 1962789..1963250 + 462 WP_000525008.1 hypothetical protein Toxin
MKI57_RS09690 (MKI57_001922) 1963434..1963955 + 522 WP_001102444.1 hypothetical protein -
MKI57_RS09695 (MKI57_001923) 1963948..1964418 + 471 WP_000183249.1 hypothetical protein -
MKI57_RS09700 (MKI57_001924) 1964488..1965534 + 1047 WP_001145732.1 tyrosine-type recombinase/integrase -
MKI57_RS09705 (MKI57_001925) 1965579..1966724 + 1146 WP_001245449.1 radical SAM/CxCxxxxC motif protein YfkAB -
MKI57_RS09710 (MKI57_001926) 1966984..1967514 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1921081..1965534 44453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18034.35 Da        Isoelectric Point: 4.6899

>T236476 WP_000525008.1 NZ_CP092538:1962789-1963250 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T236476 NZ_LR594668:549097-549942 [Variovorax sp. SRS16]
ATGAGCCGCAACCTCGCCGCTTCCATCCTCTCCCGCTTGAAGCAGCGCGCCGATGCCTCGAGGCAGGACTTCAACCTGAC
GCTCACCCACTATGGGCTGGAGCGGCTGCTGTACCGGCTGTCGGTCTCGCCCCATGCGCCTAATTACCTGCTCAAGGGCG
CCCTGCTGTTTTCGCTGTGGTATGACCAACCGCATCGGCCGACGCGCGATGCGGACCTGCTGGGGTTTGGCCCGGACGAC
ATCGACTCCGCAGTTTCGGCGTTCCGCGAGATCTGCGAGATCACGGTGGAAGATGGCATCGCGTTCGACCCGGCCTCCGT
CAAGGGTTCGGTGATTCGCAAGGAAGCGGGCTACGGCGGTGTACGGATCGACCTGCAGGCGAAGTTGGACGGTGCGCGCA
TCGCACTGCAGGTGGACATCGGTTTTGGCGATGTGGTCACGCCCGTGGCGGAATCGGTGAGCTACCCGGTGCTGCTCGAG
GGCCTGCCCGCTCCACACCTGCGCACCTATCCGAAATACACCGTGGTGGCCGAGAAGTTTCATGCGGTGTGCCTGCTGGG
CATGGTCAACACGCGCATGAAGGACTATTTCGATCTGTGGGTGTTGCTGCACGAAGGTACCTTGGATACCACCGAACTGC
GCCGCGCAATCGAAGCAACGTTTGCGCGGCGGAAACTGGCATTGCCCAGCACCCTCCCCTCGGGTTTGAGTGACGCATTC
GCGCAGGATGCGGCGAAACAAAGACAGTGGGCCGCATTCCTGCAAAAGAATCGATTGGAGGCACTGGACCTCGCCGAGGT
CGTCGCGTTTTTGCGCGGCGAATTCGAGAAGCTGGGAGCTGCATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT236476 WP_001260487.1 NZ_CP092538:1962453-1962776 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT236476 NZ_LR594668:548483-549100 [Variovorax sp. SRS16]
ATGGCACTCCGCTCGGAATCAACGCTGGAACAGGCCGCCCTGGCGCTCGCCGAGCGCCAGCCGCTGCTGCGCGCACGCGA
TCTGGCTGAGCACGGCGTGGCGACGATGGTCCTCAGCCGGCTGGTTTCGGCCGGCAAGCTCGAACGAGTCGCCCGCGGCA
TCTACAGCCTGCCGGGACGCGCGCTCAGCGAGCACCGGTCCCTGGCCGAGGTCGCCCTGCGCGTGCCGCGGGGCGTGGTG
TGCCTGCTGTCGGCGCTGCGCGTCCACGACATCGGCACGCAGGCGCCGTTCGAGGTCTGGATGGCGATCCCCCATCACTC
GCCCACACCCCGCCTGGACCAACCGGCGCTGCGCGTGGTGCGCATGTCGGGGGCGGCATTGACCGAGGGCATCGAACCGG
TCGTGATCGATGGCGTGAATGTGGCCGTATTCAATGCGGCCAAGACGGTGGCCGACTGTTTCAAGTACCGCAACAAGATC
GGCCTGGACGTGGCGCTGGAGGCGCTGCGCGATGGCTGGTCGCAGCGCAAGCTGACCATGGATGCGCTGTGGCATTACGC
CACGGCGGATCGCGTGGCCAATGTCATGCGGCCCTATCTGGAAAGCATCACTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References