Detailed information of TA system TA023647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2873366..2873994
• Replicon: chromosome
• Accession: NC_012214
• Organism: Erwinia pyrifoliae Ep1/96

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D2T444
• Locus tag: EPC_RS13315
• Protein ID: WP_004156337.1
• Coordinates: 2873776..2873994 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: EPC_RS13310
• Protein ID: WP_012668861.1
• Coordinates: 2873366..2873746 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPC_RS13290	2868697..2871837	+	3141	WP_012668857.1	multidrug efflux RND transporter permease subunit	-
EPC_RS13295	2871992..2872252	+	261	WP_012668858.1	type B 50S ribosomal protein L31	-
EPC_RS13300	2872263..2872409	+	147	WP_012668859.1	type B 50S ribosomal protein L36	-
EPC_RS13305	2872866..2873219	+	354	WP_012668860.1	hypothetical protein	-
EPC_RS13310	2873366..2873746	+	381	WP_012668861.1	Hha toxicity modulator TomB	Antitoxin
EPC_RS13315	2873776..2873994	+	219	WP_004156337.1	hemolysin expression modulator Hha	Toxin
EPC_RS13320	2874293..2874610	+	318	WP_012668862.1	MGMT family protein	-
EPC_RS13325	2874633..2875190	-	558	WP_012668863.1	YbaY family lipoprotein	-
EPC_RS13330	2875413..2876273	+	861	WP_012668864.1	acyl-CoA thioesterase II	-
EPC_RS13335	2876348..2877649	-	1302	WP_012668865.1	ammonium transporter AmtB	-
EPC_RS13340	2877672..2878010	-	339	WP_012668866.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8627.06 Da
• Isoelectric Point: 8.9007

>T23647 WP_004156337.1 NC_012214:2873776-2873994 [Erwinia pyrifoliae Ep1/96]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Nucleotide

• Length: 219 bp

>T23647 NC_012214:2873776-2873994 [Erwinia pyrifoliae Ep1/96]
ATGACTGACAAACTTCTTACGAAAACTGACTACCTGATGCGCCTCAGACGTTGTCGTTCAATCGACACCCTGGAACGCGT
GATTGAAAAGAACAAGTATGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCCGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTTGCCGTCTGGAAGTTTGTCCGTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14721.47 Da
• Isoelectric Point: 4.8834

>AT23647 WP_012668861.1 NC_012214:2873366-2873746 [Erwinia pyrifoliae Ep1/96]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDCDLISQIDEYL
DDTFMLFSNYGVNTHDLQRWQKSAKRLFNIFAKECLMSQVQSSHSF

Nucleotide

• Length: 381 bp

>AT23647 NC_012214:2873366-2873746 [Erwinia pyrifoliae Ep1/96]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCACCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTACAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACTATGAATTACAAAATCAAGCATATCGAAGACTGCGATTTGATAAGTCAGATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTATGGCGTCAATACTCATGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCCTAATGAGCCAGGTTCAATCCAGCCATTCATTTTAG

Structures

Toxin

• AlphaFold DB: A0A831EPQ0