Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 42546..43456 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP092537 | ||
| Organism | Klebsiella pneumoniae strain 2021CK-00720 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | UPHL_RS26340 | Protein ID | WP_004026354.1 |
| Coordinates | 42986..43456 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | UPHL_RS26335 | Protein ID | WP_004026357.1 |
| Coordinates | 42546..42989 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| UPHL_RS26305 (UPHL_005242) | 37564..38085 | + | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
| UPHL_RS26310 (UPHL_005243) | 38082..39035 | + | 954 | Protein_43 | ferric citrate uptake sigma factor regulator FecR | - |
| UPHL_RS26315 (UPHL_005244) | 39122..41248 | + | 2127 | WP_029884227.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| UPHL_RS26320 (UPHL_005245) | 41323..41448 | + | 126 | Protein_45 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| UPHL_RS26325 (UPHL_005246) | 41623..41844 | + | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
| UPHL_RS26330 (UPHL_005247) | 41942..42445 | + | 504 | Protein_47 | DUF4113 domain-containing protein | - |
| UPHL_RS26335 (UPHL_005248) | 42546..42989 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| UPHL_RS26340 (UPHL_005249) | 42986..43456 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| UPHL_RS26345 (UPHL_005250) | 43911..44099 | - | 189 | WP_223271245.1 | hypothetical protein | - |
| UPHL_RS26350 (UPHL_005251) | 44713..44973 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| UPHL_RS26355 (UPHL_005252) | 45544..46725 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
| UPHL_RS26360 (UPHL_005253) | 46797..46955 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| UPHL_RS26365 (UPHL_005254) | 47334..47576 | - | 243 | WP_071826037.1 | hypothetical protein | - |
| UPHL_RS26370 (UPHL_005255) | 47652..47816 | - | 165 | WP_011154586.1 | hypothetical protein | - |
| UPHL_RS26375 (UPHL_005256) | 47933..48094 | - | 162 | WP_164507110.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..235474 | 235474 | |
| - | flank | IS/Tn | - | - | 45544..46725 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T236469 WP_004026354.1 NZ_CP092537:42986-43456 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T236469 NZ_LR594664:c307326-307045 [Variovorax sp. RA8]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT236469 WP_004026357.1 NZ_CP092537:42546-42989 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT236469 NZ_LR594664:c307576-307313 [Variovorax sp. RA8]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |