23646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1739491..1741174 Replicon chromosome
Accession NC_012214
Organism Erwinia pyrifoliae Ep1/96

Toxin (Protein)


Gene name mosT Uniprot ID E3DHX2
Locus tag EPC_RS07945 Protein ID WP_012667837.1
Coordinates 1740257..1741174 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID D2T9Q4
Locus tag EPC_RS07940 Protein ID WP_012667836.1
Coordinates 1739491..1740264 (+) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPC_RS20305 1735175..1735537 + 363 WP_014538840.1 PTS galactitol transporter subunit IIA -
EPC_RS07925 1735794..1737128 - 1335 WP_012667833.1 cation:proton antiporter -
EPC_RS07930 1737223..1737789 - 567 WP_041473991.1 NAD(P)H-dependent oxidoreductase -
EPC_RS07935 1738029..1739006 + 978 WP_012667835.1 porphobilinogen synthase -
EPC_RS07940 1739491..1740264 + 774 WP_012667836.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
EPC_RS07945 1740257..1741174 + 918 WP_012667837.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EPC_RS07950 1741253..1742515 - 1263 WP_012667838.1 translesion error-prone DNA polymerase V subunit UmuC -
EPC_RS07955 1742518..1742937 - 420 WP_012667839.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
EPC_RS07960 1743109..1743840 - 732 WP_012667840.1 DUF1275 domain-containing protein -
EPC_RS07965 1744555..1745364 + 810 WP_012667841.1 trehalose-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1729648..1741174 11526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34288.50 Da        Isoelectric Point: 4.8381

>T23646 WP_012667837.1 NC_012214:1740257-1741174 [Erwinia pyrifoliae Ep1/96]
MDKQSPYYRQVALLLSALPVVAAERCFALKGGTAINLFVRDFPRLSVDIDLAYVLLESRDVALPNVRAALMRIAEILQQQ
AGISAVLQTNHSDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDIVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHQRPLSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGCIPKGKHIQALAKLEAVLAEWIK

Download         Length: 918 bp

>T23646 NC_012214:1740257-1741174 [Erwinia pyrifoliae Ep1/96]
ATGGATAAGCAATCACCTTATTATCGGCAAGTTGCGTTGCTGCTCAGCGCATTGCCTGTTGTGGCAGCAGAGCGATGCTT
TGCACTAAAAGGTGGAACGGCTATAAACTTGTTTGTCCGTGATTTTCCACGTTTATCGGTTGATATCGATTTGGCTTACG
TTTTGCTGGAAAGCAGAGATGTGGCATTGCCAAATGTTCGGGCTGCTTTGATGCGTATTGCTGAAATACTGCAACAACAG
GCTGGCATTTCGGCGGTGCTACAAACGAATCATTCTGATGAAATGCGCATTGTGGTTTCTTCTCAGGAGGCACAGATAAA
GATAGAAGTTTCGCCTGTTGCGCGAGGCACACTCTATCCCCCAGAAGAACGTGATATTGTTGAAGCGGTAGAGGACGAGT
TCGGTTTCGCTACTATTCAGGTTGTATCGCTTGCCGATCTCTATGGTGGCAAGCTTTGTGCTGCGCTTGACAGGCAACAT
CCCCGTGATTTTTATGACGTCAAAATGCTACTCGAAACGCAAGGCATTGATCGCCAGATCTTTAATGGTTTCATCACCTA
TCTATTGGGACACCAACGCCCATTATCAGAGGTGCTTAATCCCCGCTGGAAAGATATTTCTGAGCTATATGCGAATGAAT
TTAACGGAATGACATTCGATGCGGTTTCTCTGGAAGAACTCAATGCGATACCCAACTTAATGGTTACTGCTCTCAAAGCA
CAATTCACGCAGCAGGATTATGATTTTTTGATGTCTTTCAAAAGTGGTCAACCGGACTGGAGTCTGGCTCCTGAAGATCA
GATTCAGCATCTACCAGCGGTTAAGTGGAAGTTGCAAAATATTGGGTGCATACCAAAAGGTAAGCATATTCAGGCGTTGG
CGAAGCTTGAGGCTGTTCTTGCCGAGTGGATAAAGTAG

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28877.26 Da        Isoelectric Point: 10.0532

>AT23646 WP_012667836.1 NC_012214:1739491-1740264 [Erwinia pyrifoliae Ep1/96]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPQWNDAVLCLQNQLGISVHLAGLT
SLTWQGRSHYLHLTRQAIWLYVEDKASLPKWFKEFPNVEWLLLSNQKLNMNDEKYLTAVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVTRIDKANIDLGAGKRQIVSGGKLDLK
YQITVPASFVSKGISHG

Download         Length: 774 bp

>AT23646 NC_012214:1739491-1740264 [Erwinia pyrifoliae Ep1/96]
ATGTCATCAAAACTAAACTGGCTTTTGCAGAACACTGCGCCTGGCTCCTTGGTATTACAGTCCTGGTTGACAAAAAATGG
TATTAGCCCTTCTTTAGCCAATAAGTATATGCATAGTGACTGGTTACAAAAGCTACGTGCCGGTGTATACGTGCGGAGTG
GGCGTGAACCTCAGTGGAACGATGCCGTCTTATGCCTGCAAAATCAGCTGGGGATTTCTGTGCATCTGGCGGGGCTTACC
AGCCTGACCTGGCAGGGACGCTCTCATTATCTTCACTTAACGCGCCAGGCAATTTGGCTTTACGTAGAAGACAAAGCTTC
GTTGCCAAAGTGGTTCAAAGAATTTCCCAATGTCGAGTGGCTTTTACTTTCTAATCAGAAGCTCAATATGAATGACGAAA
AGTATCTGACAGCGGTAGAAATTAAGGGTGAGCGGTTGAAAGCGAGTGTGCCGGAATTAGCTGCTTACGAGATTGCTAAT
GCAGTCCCTGGTTCGCTGTCATTTGAGCACGCTGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCACGTAAAGTCGA
AGTGTTGTTGCAATCCAGTCGAGCAGTGAAAACTAACCGCCTTTACCTGTTTCTGGCCGATCATTATGCTCATGCATGGG
TTACGCGAATAGATAAAGCCAACATTGATTTAGGGGCCGGGAAACGGCAGATCGTATCTGGTGGCAAGCTGGATCTAAAA
TATCAGATCACTGTTCCAGCGAGTTTTGTTAGCAAAGGGATCTCACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3DHX2

Antitoxin

Source ID Structure
AlphaFold DB D2T9Q4

References