Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800834..801491 Replicon chromosome
Accession NZ_CP092536
Organism Klebsiella pneumoniae strain 2021CK-00720

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag UPHL_RS03945 Protein ID WP_002916310.1
Coordinates 801081..801491 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag UPHL_RS03940 Protein ID WP_002916312.1
Coordinates 800834..801100 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UPHL_RS03915 (796042) 796042..797475 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
UPHL_RS03920 (797594) 797594..798322 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
UPHL_RS03925 (798372) 798372..798683 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
UPHL_RS03930 (798847) 798847..799506 + 660 WP_002916317.1 hemolysin III family protein -
UPHL_RS03935 (799605) 799605..800588 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
UPHL_RS03940 (800834) 800834..801100 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
UPHL_RS03945 (801081) 801081..801491 + 411 WP_002916310.1 protein YgfX Toxin
UPHL_RS03950 (801498) 801498..802019 - 522 WP_002916308.1 flavodoxin FldB -
UPHL_RS03955 (802120) 802120..803016 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
UPHL_RS03960 (803039) 803039..803752 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
UPHL_RS03965 (803758) 803758..805491 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T236455 WP_002916310.1 NZ_CP092536:801081-801491 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T236455 NZ_LR594051:2765039-2765182 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT236455 WP_002916312.1 NZ_CP092536:800834-801100 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236455 NZ_LR594051:c2765299-2765115 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References