Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 4417989..4418486 | Replicon | chromosome |
| Accession | NZ_CP092534 | ||
| Organism | Escherichia coli strain DS566 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | L4JJG6 |
| Locus tag | MKD44_RS21555 | Protein ID | WP_001173343.1 |
| Coordinates | 4417989..4418162 (-) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | S1NQ59 |
| Locus tag | MKD44_RS21560 | Protein ID | WP_001312331.1 |
| Coordinates | 4418190..4418486 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKD44_RS21545 (4414659) | 4414659..4416116 | + | 1458 | WP_000856826.1 | dipeptide/tripeptide permease DtpC | - |
| MKD44_RS21550 (4416353) | 4416353..4417870 | + | 1518 | WP_000003806.1 | lysine--tRNA ligase | - |
| MKD44_RS21555 (4417989) | 4417989..4418162 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
| MKD44_RS21560 (4418190) | 4418190..4418486 | - | 297 | WP_001312331.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| MKD44_RS21565 (4418715) | 4418715..4418987 | - | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
| MKD44_RS21570 (4418999) | 4418999..4419229 | - | 231 | WP_000373293.1 | 4Fe-4S mono-cluster protein YjdI | - |
| MKD44_RS21575 (4419410) | 4419410..4421041 | + | 1632 | WP_001216482.1 | sensor histidine kinase | - |
| MKD44_RS21580 (4421038) | 4421038..4421757 | + | 720 | WP_001540474.1 | two-component system response regulator DcuR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4362090..4418486 | 56396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T236451 WP_001173343.1 NZ_CP092534:c4418162-4417989 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T236451 NZ_LR594050:661202-661984 [Streptococcus porcinus]
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCGACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGTAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGATTGACGAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACCTTACGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAATTGTCATATCTCAGCACCTTAATTCGTTACGAGGAA
CTTTATGCCATAGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGTTAGAAAGTGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGAGTTGTATCTACGATTCTG
AAACAGATGAAGGTTCCGCAGCAGAAGTGTTACAAGACTGCCTCTTCGGAAAATGGAGTAAAGTTGAGGAAGGGATGTTG
CAAATAGAGAAAGATAGATTAAAAAGGCTATATAAAGTTAAGGAGAATGGAAATAGTTTATGA
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCGACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGTAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGATTGACGAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACCTTACGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAATTGTCATATCTCAGCACCTTAATTCGTTACGAGGAA
CTTTATGCCATAGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGTTAGAAAGTGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGAGTTGTATCTACGATTCTG
AAACAGATGAAGGTTCCGCAGCAGAAGTGTTACAAGACTGCCTCTTCGGAAAATGGAGTAAAGTTGAGGAAGGGATGTTG
CAAATAGAGAAAGATAGATTAAAAAGGCTATATAAAGTTAAGGAGAATGGAAATAGTTTATGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11440.95 Da Isoelectric Point: 4.1705
>AT236451 WP_001312331.1 NZ_CP092534:c4418486-4418190 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
Download Length: 297 bp
>AT236451 NZ_LR594050:660726-661202 [Streptococcus porcinus]
ATGATTGGAGACAATATCAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTAAGTCGTTATGAAAATGGAACCAGCACTGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAGAATAGAA
GTGATCAAAGAACGTGGAGCAGCCATATTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACAAAGATTTACCTTGTCGATACTTTCGATG
AGATTGAGCGTTACAATGGTTATTTAGACGGTATTGAGCGGATGTTAGAGATGGTGCATCATCGGGTGGTGGCTTAA
ATGATTGGAGACAATATCAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTAAGTCGTTATGAAAATGGAACCAGCACTGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAGAATAGAA
GTGATCAAAGAACGTGGAGCAGCCATATTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACAAAGATTTACCTTGTCGATACTTTCGATG
AGATTGAGCGTTACAATGGTTATTTAGACGGTATTGAGCGGATGTTAGAGATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QI41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NQ59 |