Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3756241..3756770 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JTY_RS17620 Protein ID WP_003417760.1
Coordinates 3756513..3756770 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JTY_RS17615 Protein ID WP_003417757.1
Coordinates 3756241..3756516 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS17580 3751272..3752570 - 1299 WP_011799343.1 PPE family protein -
JTY_RS22600 3753039..3754476 - 1438 Protein_3438 FAD-binding oxidoreductase -
JTY_RS17600 3754579..3754968 + 390 WP_010950876.1 DUF732 domain-containing protein -
JTY_RS17605 3754982..3755275 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JTY_RS17610 3755272..3756117 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JTY_RS17615 3756241..3756516 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JTY_RS17620 3756513..3756770 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JTY_RS17625 3756812..3758002 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JTY_RS17630 3758119..3758487 + 369 WP_003417765.1 FHA domain-containing protein -
JTY_RS17635 3758484..3759035 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JTY_RS17640 3759042..3759623 - 582 WP_003417769.1 ATP/GTP-binding protein -
JTY_RS17645 3759604..3759972 - 369 WP_003417772.1 DUF742 domain-containing protein -
JTY_RS17650 3759950..3760342 - 393 WP_011799344.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T23643 WP_003417760.1 NC_012207:3756513-3756770 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T23643 NC_012207:3756513-3756770 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT23643 WP_003417757.1 NC_012207:3756241-3756516 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT23643 NC_012207:3756241-3756516 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References