Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
Location | 4417813..4418310 | Replicon | chromosome |
Accession | NZ_CP092533 | ||
Organism | Escherichia coli strain DS566-1 |
Toxin (Protein)
Gene name | ghoT | Uniprot ID | L4JJG6 |
Locus tag | MKD47_RS21550 | Protein ID | WP_001173343.1 |
Coordinates | 4417813..4417986 (-) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | ghoS | Uniprot ID | S1NQ59 |
Locus tag | MKD47_RS21555 | Protein ID | WP_001312331.1 |
Coordinates | 4418014..4418310 (-) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKD47_RS21540 (4414483) | 4414483..4415940 | + | 1458 | WP_000856826.1 | dipeptide/tripeptide permease DtpC | - |
MKD47_RS21545 (4416177) | 4416177..4417694 | + | 1518 | WP_000003806.1 | lysine--tRNA ligase | - |
MKD47_RS21550 (4417813) | 4417813..4417986 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
MKD47_RS21555 (4418014) | 4418014..4418310 | - | 297 | WP_001312331.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
MKD47_RS21560 (4418539) | 4418539..4418811 | - | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
MKD47_RS21565 (4418823) | 4418823..4419053 | - | 231 | WP_000373293.1 | 4Fe-4S mono-cluster protein YjdI | - |
MKD47_RS21570 (4419234) | 4419234..4420865 | + | 1632 | WP_001216482.1 | sensor histidine kinase | - |
MKD47_RS21575 (4420862) | 4420862..4421581 | + | 720 | WP_001540474.1 | two-component system response regulator DcuR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4361914..4418310 | 56396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T236423 WP_001173343.1 NZ_CP092533:c4417986-4417813 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T236423 NZ_LR594037:c1280096-1279731 [Streptococcus anginosus]
GTGCATAATATCTATTTTTACAAAGATAAAAACGGGAATGAGCCGGTTTTAGATTATATGCGTGAACTTGCCAGCAAAAA
AGGCAAGGATAGTCGTATCAAACTAAACAAGATAAATGACTATATCGAACTACTAAGCCAACGTGGTACACGCGCAGGAG
AACCGTATATTAAGCATTTAGATGCTGAAATTTGGGAGCTTAGACCATTGAGGGATAGGATATTATTTGTTGCTTGGATT
GATGGCAACTTTGTATTGTTGCATCATTTTATGAAAAAGACGCAGAAAACACCAAAACGAGAAATTGAACAAGCAAAGCG
TGAATTACGCGACTTAAAAGAAAGAGGGCTATACAATGAAAAATAG
GTGCATAATATCTATTTTTACAAAGATAAAAACGGGAATGAGCCGGTTTTAGATTATATGCGTGAACTTGCCAGCAAAAA
AGGCAAGGATAGTCGTATCAAACTAAACAAGATAAATGACTATATCGAACTACTAAGCCAACGTGGTACACGCGCAGGAG
AACCGTATATTAAGCATTTAGATGCTGAAATTTGGGAGCTTAGACCATTGAGGGATAGGATATTATTTGTTGCTTGGATT
GATGGCAACTTTGTATTGTTGCATCATTTTATGAAAAAGACGCAGAAAACACCAAAACGAGAAATTGAACAAGCAAAGCG
TGAATTACGCGACTTAAAAGAAAGAGGGCTATACAATGAAAAATAG
Antitoxin
Download Length: 99 a.a. Molecular weight: 11440.95 Da Isoelectric Point: 4.1705
>AT236423 WP_001312331.1 NZ_CP092533:c4418310-4418014 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
Download Length: 297 bp
>AT236423 NZ_LR594037:c1279741-1279445 [Streptococcus anginosus]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTGAGAGCTGAACTTTTTTCCAAAGAGGAAATTTTGGAGAGTGA
TATGCGCGTGGCAATCATGAGTGAGCTGATTGATGCTAGAAATGAAAAAGGGATCAGTCAGAAAAAACTTGAGGAACTAA
GCGGAGTAAGTCAGCCAGTTATTGCTAGAATGGAAACAGGTAAGACAAGTCCACAACTTGATACTGTTTTAAAAGTCTTG
GCAAGTCTTGGGAAAACTTTGGCAGTTGTACCCTTAGAGGGCGAACAGGTAAGCTAG
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTGAGAGCTGAACTTTTTTCCAAAGAGGAAATTTTGGAGAGTGA
TATGCGCGTGGCAATCATGAGTGAGCTGATTGATGCTAGAAATGAAAAAGGGATCAGTCAGAAAAAACTTGAGGAACTAA
GCGGAGTAAGTCAGCCAGTTATTGCTAGAATGGAAACAGGTAAGACAAGTCCACAACTTGATACTGTTTTAAAAGTCTTG
GCAAGTCTTGGGAAAACTTTGGCAGTTGTACCCTTAGAGGGCGAACAGGTAAGCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QI41 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1NQ59 |