Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4406018..4406850 Replicon chromosome
Accession NZ_CP092533
Organism Escherichia coli strain DS566-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag MKD47_RS21505 Protein ID WP_000854753.1
Coordinates 4406476..4406850 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag MKD47_RS21500 Protein ID WP_001540478.1
Coordinates 4406018..4406386 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD47_RS21465 (4401851) 4401851..4402531 + 681 WP_001282919.1 WYL domain-containing protein -
MKD47_RS21470 (4402679) 4402679..4403356 + 678 WP_001097301.1 hypothetical protein -
MKD47_RS21475 (4403362) 4403362..4403595 + 234 WP_001278283.1 DUF905 family protein -
MKD47_RS21480 (4403685) 4403685..4404503 + 819 WP_001773857.1 DUF932 domain-containing protein -
MKD47_RS21485 (4404594) 4404594..4405079 + 486 WP_000214398.1 antirestriction protein -
MKD47_RS21490 (4405095) 4405095..4405571 + 477 WP_001186786.1 RadC family protein -
MKD47_RS21495 (4405634) 4405634..4405855 + 222 WP_000692311.1 DUF987 domain-containing protein -
MKD47_RS21500 (4406018) 4406018..4406386 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MKD47_RS21505 (4406476) 4406476..4406850 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
MKD47_RS21510 (4406847) 4406847..4407335 + 489 WP_000777545.1 DUF5983 family protein -
MKD47_RS21515 (4407347) 4407347..4407544 + 198 WP_000839281.1 DUF957 domain-containing protein -
MKD47_RS21520 (4407641) 4407641..4408210 + 570 WP_001560692.1 DUF4942 domain-containing protein -
MKD47_RS21525 (4408959) 4408959..4410497 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4361914..4418310 56396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T236422 WP_000854753.1 NZ_CP092533:4406476-4406850 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T236422 NZ_LR594037:c131244-130990 [Streptococcus anginosus]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAGGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATAGAGGATATCAAACGGAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATATCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACAACGATTAGTCTATATGGTGGAAAAAGATGAGATTTATTTCTTATCCTTTAGA
GACCATTACACATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT236422 WP_001540478.1 NZ_CP092533:4406018-4406386 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT236422 NZ_LR594037:c131503-131237 [Streptococcus anginosus]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAACATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTAGTCTTATCTAAGAAAAATTGGGATAGTATCCAAGAAACCATCC
GTCTAATGAATAACGAGTACCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAACCATTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References