Detailed information of TA system TA236421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4147785..4148599
• Replicon: chromosome
• Accession: NZ_CP092533
• Organism: Escherichia coli strain DS566-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: MKD47_RS20170
• Protein ID: WP_001054376.1
• Coordinates: 4147785..4148042 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: S1NWL7
• Locus tag: MKD47_RS20175
• Protein ID: WP_001540600.1
• Coordinates: 4148054..4148599 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD47_RS20145 (4143073)	4143073..4144179	+	1107	WP_001774143.1	N-acetylneuraminate epimerase	-
MKD47_RS20150 (4144244)	4144244..4145224	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
MKD47_RS20155 (4145334)	4145334..4145539	+	206	Protein_3944	HNH endonuclease	-
MKD47_RS20160 (4145807)	4145807..4147047	-	1241	Protein_3945	helicase YjhR	-
MKD47_RS20165 (4147163)	4147163..4147294	+	132	WP_001309182.1	hypothetical protein	-
MKD47_RS20170 (4147785)	4147785..4148042	+	258	WP_001054376.1	YjhX family toxin	Toxin
MKD47_RS20175 (4148054)	4148054..4148599	+	546	WP_001540600.1	N-acetyltransferase	Antitoxin
MKD47_RS20180 (4148655)	4148655..4149401	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
MKD47_RS20185 (4149570)	4149570..4149788	+	219	Protein_3950	hypothetical protein	-
MKD47_RS20190 (4149826)	4149826..4149942	+	117	Protein_3951	VOC family protein	-
MKD47_RS20195 (4150187)	4150187..4151308	+	1122	WP_000010829.1	M42 family metallopeptidase	-
MKD47_RS20200 (4151305)	4151305..4151583	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
MKD47_RS20205 (4151595)	4151595..4152908	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4137571..4156823	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T236421 WP_001054376.1 NZ_CP092533:4147785-4148042 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T236421 NZ_LR594036:1101000-1101845 [Streptococcus porcinus]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTAGCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TATCAAATGTTATTGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCAGAAGAAGGTATATCTTTTGTGATACAATCCATCACAGCTAT
TAAAGAAAGTGATGACTATGGCGGCTATCGAGCAACAATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGCGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGATAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCGCGTAACTTCTTGAACAGCAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTAAAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCGAAAAAATATAGCTATACAAAGGGGATTTCCCTTGCGAATGTTCTTGATGA
GATGATTCATCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19926.87 Da
• Isoelectric Point: 6.3277

>AT236421 WP_001540600.1 NZ_CP092533:4148054-4148599 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT236421 NZ_LR594036:1100413-1101003 [Streptococcus porcinus]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAATTCTATACCGTGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCGAAAGCTGTTTTCTCATATATCTCAGCGCTTTATCTG
CAACAATTTACAGATGAAATCCCTCAATATTTTGACGTAACCATTCCTAGAGGTTACCGTTTTAATACTCCTCCAGCTAA
TCTGAACATTCATTCCGTTTCTAAGGAAAATAGCGAACTAGGAATTACTCTTGTAAAAACCCCTATGGGAAATGAGGTAA
GAGTCTATGATTTCGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACTTTACGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACTAAATTGAACACCTTGGCCAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: S1NWL7