Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3694110..3694784 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JTY_RS17415 Protein ID WP_003417282.1
Coordinates 3694110..3694538 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JTY_RS17420 Protein ID WP_003417286.1
Coordinates 3694542..3694784 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS17390 3689931..3690332 - 402 WP_003417264.1 cytidine deaminase -
JTY_RS17395 3690473..3690907 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
JTY_RS17400 3690904..3691338 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JTY_RS17405 3691467..3693240 + 1774 Protein_3400 succinate dehydrogenase flavoprotein subunit -
JTY_RS17410 3693240..3694031 + 792 WP_012666361.1 succinate dehydrogenase iron-sulfur subunit -
JTY_RS17415 3694110..3694538 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JTY_RS17420 3694542..3694784 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
JTY_RS17425 3694906..3695520 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JTY_RS17430 3695517..3696182 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JTY_RS17435 3696183..3696716 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JTY_RS17440 3696713..3697087 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JTY_RS17445 3697184..3698248 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T23642 WP_003417282.1 NC_012207:c3694538-3694110 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T23642 NC_012207:c3694538-3694110 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT23642 WP_003417286.1 NC_012207:c3694784-3694542 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT23642 NC_012207:c3694784-3694542 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References