Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3124296..3124844 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JTY_RS14835 Protein ID WP_003414602.1
Coordinates 3124581..3124844 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JTY_RS14830 Protein ID WP_003414599.1
Coordinates 3124296..3124577 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS14805 3119919..3120776 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JTY_RS14810 3120818..3121402 - 585 WP_010950792.1 DUF1707 domain-containing protein -
JTY_RS14815 3121506..3121754 + 249 WP_003913411.1 antitoxin VapB23 -
JTY_RS14820 3121751..3122131 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JTY_RS14825 3122213..3124024 - 1812 WP_003414596.1 penicillin-binding protein -
JTY_RS14830 3124296..3124577 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JTY_RS14835 3124581..3124844 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JTY_RS14840 3125217..3126071 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JTY_RS14845 3126127..3127290 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JTY_RS14850 3127307..3128521 - 1215 WP_011799297.1 zinc metalloprotease Rip -
JTY_RS14855 3128529..3129770 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T23639 WP_003414602.1 NC_012207:3124581-3124844 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T23639 NC_012207:3124581-3124844 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT23639 WP_003414599.1 NC_012207:3124296-3124577 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT23639 NC_012207:3124296-3124577 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References