236384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3519911..3520529 Replicon chromosome
Accession NZ_CP092532
Organism Escherichia coli strain DS566-2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MKD45_RS17185 Protein ID WP_001291435.1
Coordinates 3520311..3520529 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MKD45_RS17180 Protein ID WP_000344800.1
Coordinates 3519911..3520285 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD45_RS17170 (3515000) 3515000..3516193 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MKD45_RS17175 (3516216) 3516216..3519365 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
MKD45_RS17180 (3519911) 3519911..3520285 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MKD45_RS17185 (3520311) 3520311..3520529 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MKD45_RS17190 (3520702) 3520702..3521253 + 552 WP_000102539.1 maltose O-acetyltransferase -
MKD45_RS17195 (3521369) 3521369..3521839 + 471 WP_000136192.1 YlaC family protein -
MKD45_RS17200 (3522003) 3522003..3523553 + 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MKD45_RS17205 (3523595) 3523595..3523948 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MKD45_RS17215 (3524327) 3524327..3524638 + 312 WP_000409908.1 MGMT family protein -
MKD45_RS17220 (3524669) 3524669..3525241 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T236384 WP_001291435.1 NZ_CP092532:3520311-3520529 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T236384 NZ_LR590469:c1319571-1319293 [Yersinia enterocolitica subsp. enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
GAATAAACTTAAAGTCATTATGACGCTTCTGATTAACGATAAATTGCCCTTGCCTGTTGTATATAAGGATCATCAATTAC
AAGGTAATTATAAAGGCTACAGGGACGCACATATAGAGCCAGACTGGCTTATCATCTACAAAATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT236384 WP_000344800.1 NZ_CP092532:3519911-3520285 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT236384 NZ_LR590469:c1319838-1319578 [Yersinia enterocolitica subsp. enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGACGAAACCCTAAAGAATGAAGCCGCTGCTGTACTTGCTGACATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTTGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACAGCTAATACCATTGCCAACAGCGATAAAGGTGTCGATGTCCATAAAGCAAAGGATGCTGATGATCTT
TTTGATAAATTAGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References