Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 16024..16667 | Replicon | plasmid p1 |
| Accession | NZ_CP092513 | ||
| Organism | Klebsiella quasipneumoniae strain EF262 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | MKM89_RS25780 | Protein ID | WP_021312475.1 |
| Coordinates | 16251..16667 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A6B7Q5S4 |
| Locus tag | MKM89_RS25775 | Protein ID | WP_021312476.1 |
| Coordinates | 16024..16254 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKM89_RS25750 (MKM89_25745) | 11532..12047 | + | 516 | Protein_10 | CSS-motif domain-containing protein | - |
| MKM89_RS25755 (MKM89_25750) | 12147..12947 | + | 801 | WP_065905270.1 | EAL domain-containing protein | - |
| MKM89_RS25760 (MKM89_25755) | 13634..14602 | - | 969 | WP_014839937.1 | IS5 family transposase | - |
| MKM89_RS25765 (MKM89_25760) | 14604..15077 | - | 474 | WP_065905236.1 | hypothetical protein | - |
| MKM89_RS25770 (MKM89_25765) | 15126..15419 | - | 294 | WP_124989603.1 | hypothetical protein | - |
| MKM89_RS25775 (MKM89_25770) | 16024..16254 | + | 231 | WP_021312476.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MKM89_RS25780 (MKM89_25775) | 16251..16667 | + | 417 | WP_021312475.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MKM89_RS25785 (MKM89_25780) | 16702..16947 | + | 246 | WP_065905238.1 | hypothetical protein | - |
| MKM89_RS25790 (MKM89_25785) | 17011..17229 | + | 219 | WP_021312527.1 | hypothetical protein | - |
| MKM89_RS25795 (MKM89_25790) | 17308..17634 | + | 327 | WP_124989605.1 | hypothetical protein | - |
| MKM89_RS25800 (MKM89_25795) | 17874..18137 | + | 264 | WP_004118691.1 | hypothetical protein | - |
| MKM89_RS25805 (MKM89_25800) | 18134..18700 | + | 567 | WP_009654312.1 | hypothetical protein | - |
| MKM89_RS25810 (MKM89_25805) | 18731..19225 | + | 495 | WP_016528789.1 | hypothetical protein | - |
| MKM89_RS25815 (MKM89_25810) | 19286..19489 | + | 204 | WP_004150739.1 | HHA domain-containing protein | - |
| MKM89_RS25820 (MKM89_25815) | 19538..19795 | + | 258 | WP_004098928.1 | hypothetical protein | - |
| MKM89_RS25825 (MKM89_25820) | 19871..20125 | + | 255 | WP_032731922.1 | hypothetical protein | - |
| MKM89_RS25830 (MKM89_25825) | 20424..21428 | - | 1005 | WP_065905242.1 | IS110-like element IS5075 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..203351 | 203351 | |
| - | flank | IS/Tn | - | - | 13634..14602 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15033.44 Da Isoelectric Point: 7.8915
>T236365 WP_021312475.1 NZ_CP092513:16251-16667 [Klebsiella quasipneumoniae]
VKKTFMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
VKKTFMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
Download Length: 417 bp
>T236365 NZ_LR588412:329106-329474 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTTATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTTATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8723.76 Da Isoelectric Point: 4.3410
>AT236365 WP_021312476.1 NZ_CP092513:16024-16254 [Klebsiella quasipneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
Download Length: 231 bp
>AT236365 NZ_LR588412:328888-329109 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGAAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGAAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|