Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4731521..4732034 Replicon chromosome
Accession NZ_CP092512
Organism Klebsiella quasipneumoniae strain EF262

Toxin (Protein)


Gene name relE Uniprot ID A0A5Q9LKU5
Locus tag MKM89_RS23100 Protein ID WP_048322786.1
Coordinates 4731521..4731802 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MKM89_RS23105 Protein ID WP_002886901.1
Coordinates 4731792..4732034 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKM89_RS23085 (4726568) 4726568..4728223 + 1656 WP_065802821.1 alpha,alpha-phosphotrehalase -
MKM89_RS23090 (4728609) 4728609..4730747 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
MKM89_RS23095 (4731053) 4731053..4731517 + 465 WP_023319597.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MKM89_RS23100 (4731521) 4731521..4731802 - 282 WP_048322786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKM89_RS23105 (4731792) 4731792..4732034 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKM89_RS23110 (4732112) 4732112..4734022 - 1911 WP_004206509.1 PRD domain-containing protein -
MKM89_RS23115 (4734045) 4734045..4735196 - 1152 WP_057212389.1 lactonase family protein -
MKM89_RS23120 (4735263) 4735263..4736003 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11013.82 Da        Isoelectric Point: 10.2849

>T236364 WP_048322786.1 NZ_CP092512:c4731802-4731521 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T236364 NZ_LR588411:c4964836-4964734 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT236364 WP_002886901.1 NZ_CP092512:c4732034-4731792 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT236364 NZ_LR588411:4964730-4964877 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LKU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References