Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3056388..3056958 | Replicon | chromosome |
Accession | NC_012207 | ||
Organism | Mycobacterium bovis BCG str. Tokyo 172 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | JTY_RS14480 | Protein ID | WP_003414166.1 |
Coordinates | 3056388..3056744 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | JTY_RS14485 | Protein ID | WP_003901465.1 |
Coordinates | 3056728..3056958 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTY_RS14460 | 3051840..3053528 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
JTY_RS14465 | 3053532..3053858 | - | 327 | WP_003414157.1 | hypothetical protein | - |
JTY_RS14470 | 3054031..3054618 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
JTY_RS14475 | 3054637..3056286 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
JTY_RS14480 | 3056388..3056744 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
JTY_RS14485 | 3056728..3056958 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
JTY_RS14490 | 3057001..3058044 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
JTY_RS21995 | 3058235..3058510 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
JTY_RS22000 | 3058686..3058940 | - | 255 | WP_003917684.1 | hypothetical protein | - |
JTY_RS14505 | 3059088..3059492 | + | 405 | WP_003414181.1 | hypothetical protein | - |
JTY_RS14510 | 3059489..3059680 | + | 192 | WP_003414184.1 | hypothetical protein | - |
JTY_RS14515 | 3059744..3061033 | + | 1290 | Protein_2829 | transposase family protein | - |
JTY_RS14520 | 3061267..3061524 | + | 258 | WP_003899489.1 | hypothetical protein | - |
JTY_RS14525 | 3061629..3061940 | + | 312 | WP_010950777.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T23636 WP_003414166.1 NC_012207:c3056744-3056388 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T23636 NC_012207:c3056744-3056388 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT23636 WP_003901465.1 NC_012207:c3056958-3056728 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT23636 NC_012207:c3056958-3056728 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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