Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800660..801317 Replicon chromosome
Accession NZ_CP092512
Organism Klebsiella quasipneumoniae strain EF262

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag MKM89_RS03940 Protein ID WP_004205323.1
Coordinates 800907..801317 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKM89_RS03935 Protein ID WP_002916312.1
Coordinates 800660..800926 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKM89_RS03910 (795869) 795869..797302 - 1434 WP_080936034.1 6-phospho-beta-glucosidase BglA -
MKM89_RS03915 (797421) 797421..798149 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
MKM89_RS03920 (798199) 798199..798510 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
MKM89_RS03925 (798673) 798673..799332 + 660 WP_004205319.1 hemolysin III family protein -
MKM89_RS03930 (799431) 799431..800414 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
MKM89_RS03935 (800660) 800660..800926 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKM89_RS03940 (800907) 800907..801317 + 411 WP_004205323.1 protein YgfX Toxin
MKM89_RS03945 (801324) 801324..801845 - 522 WP_004205324.1 flavodoxin FldB -
MKM89_RS03950 (801946) 801946..802842 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MKM89_RS03955 (802865) 802865..803578 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKM89_RS03960 (803584) 803584..805317 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T236353 WP_004205323.1 NZ_CP092512:800907-801317 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T236353 NZ_LR588408:c3800283-3799966 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT236353 WP_002916312.1 NZ_CP092512:800660-800926 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236353 NZ_LR588408:c3799973-3799686 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References