236352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 51569..52170 Replicon plasmid pMFDS1011659
Accession NZ_CP092511
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name doc Uniprot ID A0A731GHK2
Locus tag MKE90_RS23860 Protein ID WP_001216038.1
Coordinates 51790..52170 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag MKE90_RS23855 Protein ID WP_001190712.1
Coordinates 51569..51790 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS23800 (MKE90_23795) 46993..47196 + 204 WP_000158003.1 hypothetical protein -
MKE90_RS23805 (MKE90_23800) 47189..47428 + 240 WP_000476201.1 hypothetical protein -
MKE90_RS23810 (MKE90_23805) 47425..48150 + 726 WP_000078034.1 ead/Ea22-like family protein -
MKE90_RS23815 (MKE90_23810) 48152..48346 + 195 WP_000224731.1 hypothetical protein -
MKE90_RS23820 (MKE90_23815) 48348..48557 + 210 WP_271232209.1 hypothetical protein -
MKE90_RS23825 (MKE90_23820) 48554..49720 + 1167 WP_000208025.1 hypothetical protein -
MKE90_RS23830 (MKE90_23825) 49704..49988 + 285 WP_001142397.1 hypothetical protein -
MKE90_RS23835 (MKE90_23830) 49973..50323 - 351 WP_001436207.1 hypothetical protein -
MKE90_RS23840 (MKE90_23835) 50356..50454 + 99 Protein_69 DNA polymerase III subunit theta -
MKE90_RS23845 (MKE90_23840) 50514..50903 + 390 WP_000506729.1 S24 family peptidase -
MKE90_RS23850 (MKE90_23845) 51038..51460 + 423 WP_000098854.1 hypothetical protein -
MKE90_RS23855 (MKE90_23850) 51569..51790 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKE90_RS23860 (MKE90_23855) 51790..52170 + 381 WP_001216038.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MKE90_RS23865 (MKE90_23860) 52175..52372 + 198 WP_000113017.1 hypothetical protein -
MKE90_RS23870 (MKE90_23865) 52405..53181 - 777 WP_271232210.1 hypothetical protein -
MKE90_RS23875 (MKE90_23870) 53188..53865 - 678 WP_001061874.1 DUF2829 domain-containing protein -
MKE90_RS23880 (MKE90_23875) 53880..54374 - 495 WP_000640907.1 dUTP diphosphatase -
MKE90_RS23885 (MKE90_23880) 54371..54847 - 477 WP_000861175.1 hypothetical protein -
MKE90_RS23890 (MKE90_23885) 54844..55188 - 345 WP_001191776.1 hypothetical protein -
MKE90_RS23895 (MKE90_23890) 55262..56290 - 1029 WP_001292235.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92361 92361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T236352 WP_001216038.1 NZ_CP092511:51790-52170 [Salmonella enterica subsp. enterica serovar Thompson]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEISDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T236352 NZ_LR588408:c2633764-2632442 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAA
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCCTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGTACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT236352 WP_001190712.1 NZ_CP092511:51569-51790 [Salmonella enterica subsp. enterica serovar Thompson]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT236352 NZ_LR588408:c2634030-2633764 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCATCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A731GHK2

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References