Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4150827..4151343 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag MKE90_RS20280 Protein ID WP_000220578.1
Coordinates 4150827..4151111 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MKE90_RS20285 Protein ID WP_000212724.1
Coordinates 4151101..4151343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS20265 (4145943) 4145943..4147595 + 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -
MKE90_RS20270 (4148004) 4148004..4150142 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MKE90_RS20275 (4150359) 4150359..4150823 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MKE90_RS20280 (4150827) 4150827..4151111 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKE90_RS20285 (4151101) 4151101..4151343 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKE90_RS20290 (4151421) 4151421..4153334 - 1914 WP_001212135.1 BglG family transcription antiterminator -
MKE90_RS20295 (4153351) 4153351..4154091 - 741 WP_023193113.1 KDGP aldolase family protein -
MKE90_RS20300 (4154088) 4154088..4155206 - 1119 WP_017465839.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MKE90_RS20305 (4155190) 4155190..4156323 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T236348 WP_000220578.1 NZ_CP092510:c4151111-4150827 [Salmonella enterica subsp. enterica serovar Thompson]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T236348 NZ_LR536843:c1716489-1716235 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT236348 WP_000212724.1 NZ_CP092510:c4151343-4151101 [Salmonella enterica subsp. enterica serovar Thompson]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT236348 NZ_LR536843:c1716733-1716491 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References