Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3434230..3434850 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MKE90_RS16945 Protein ID WP_001280991.1
Coordinates 3434632..3434850 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MKE90_RS16940 Protein ID WP_000344807.1
Coordinates 3434230..3434604 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS16930 (3429369) 3429369..3430562 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MKE90_RS16935 (3430585) 3430585..3433734 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MKE90_RS16940 (3434230) 3434230..3434604 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MKE90_RS16945 (3434632) 3434632..3434850 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MKE90_RS16950 (3435029) 3435029..3435580 + 552 WP_001278793.1 maltose O-acetyltransferase -
MKE90_RS16955 (3435698) 3435698..3436168 + 471 WP_000136183.1 YlaC family protein -
MKE90_RS16960 (3436224) 3436224..3436364 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MKE90_RS16965 (3436370) 3436370..3436630 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MKE90_RS16970 (3436855) 3436855..3438405 + 1551 WP_000213139.1 EAL domain-containing protein -
MKE90_RS16980 (3438636) 3438636..3439025 + 390 WP_000961285.1 MGMT family protein -
MKE90_RS16985 (3439058) 3439058..3439627 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T236344 WP_001280991.1 NZ_CP092510:3434632-3434850 [Salmonella enterica subsp. enterica serovar Thompson]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T236344 NZ_LR536452:28367-28789 [Methylocella tundrae]
ATGAATTTCCTTCTCGACACGAATGTGCTGTCGGAGGCGCAGCGGCCAACGCCAAGCGCCAGAGCCCTCGCCTGGCTCGA
CGCCATCGACGAGGACCGCGTCTTCCTGAGCGTCGCCTCGATCGCCGAGCTCCGGCGCGGCGTCGCCTTGCTTGATGAGG
GCCGCCGCCGCTCGGCGCTCGCCGCCTGGCTCGCCAATGATCTTCCGGCGCGGTTTGGCGGCCGGATTCTCCCAATCGAT
CAGGCGGTTGCGGAGCGCTGGGGCGACCTGATGGCCGAGAGCCGGAAAACCGGGACCGCGCTCTCCGCCATGGACGGTTT
TTTCGCGGCGACGGCGCTCGCCAGGGAGCTCACGCTCGTCACCCGCAACGTCAAGGATTTTGCGCCTTTCGGCGTGGCTT
TGCTCAACCCCTGGGAGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT236344 WP_000344807.1 NZ_CP092510:3434230-3434604 [Salmonella enterica subsp. enterica serovar Thompson]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT236344 NZ_LR536452:28092-28370 [Methylocella tundrae]
ATGCCCGCTCCCGACAAAACCGCTGCCCCGGCCGCCGGCGCCTGGACGCTCGCCAGCGCCAAGGCGCGCCTCTCCGAAGT
GGTCGAGCGCGCCCAGGCCTCGCCTCAGCTCATCACCCGCAACGGCAAGCCGGCCGCCGTGATCGTCTCGGCCGAGGAAT
GGGCGAAGAAGACCCTCCGAAAAGGCACGCTCGCCGAGTTCCTGCTCGCCTCTCCGCTTCGCGGCGCCGGGCTCGACCTC
GAGCGCCAGCGCGACGCGCCGCGCGACATCGCCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References