236343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2390910..2391432 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MKE90_RS11745 Protein ID WP_000221343.1
Coordinates 2391148..2391432 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MKE90_RS11740 Protein ID WP_000885424.1
Coordinates 2390910..2391158 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS11720 (2386631) 2386631..2387638 - 1008 WP_000201074.1 LacI family DNA-binding transcriptional regulator -
MKE90_RS11725 (2387896) 2387896..2389362 + 1467 WP_000987828.1 hypothetical protein -
MKE90_RS11730 (2389664) 2389664..2389954 + 291 WP_000742001.1 hypothetical protein -
MKE90_RS11735 (2390307) 2390307..2390762 + 456 Protein_2296 helix-turn-helix domain-containing protein -
MKE90_RS11740 (2390910) 2390910..2391158 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKE90_RS11745 (2391148) 2391148..2391432 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKE90_RS11750 (2391603) 2391603..2391992 + 390 WP_271232205.1 RidA family protein -
MKE90_RS11755 (2392044) 2392044..2393123 - 1080 WP_017465711.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MKE90_RS11760 (2393316) 2393316..2393804 - 489 WP_017465710.1 MarR family winged helix-turn-helix transcriptional regulator -
MKE90_RS11765 (2393849) 2393849..2395357 + 1509 WP_017465709.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2387899..2398214 10315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T236343 WP_000221343.1 NZ_CP092510:2391148-2391432 [Salmonella enterica subsp. enterica serovar Thompson]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T236343 NZ_LR536450:2017704-2018030 [Methylocella tundrae]
ATGAAGCGCGGCCAATTCGTGGTCGTTGCGACATCGGGCGATTACGGCAAGCCGCGTCCCGCGCTCGTCATGCAAAGTGA
TCTTTTCGCCGAACTGCCGTCCGCCATCATTTGTCCCTTGACGACGACGCTGCGCGACGATGCGGATTTGTTTCGGTTGG
AAGTCTCGCCTTCCCCCCGAAATGGATTGCGAGAGATTTCTCAAATCGCGATCGACAAACTCACTGTCGTTCCCATCGCC
AAGATCGGCGACGTGATCGGCCAAGCCGACGACGCCCTGCTCCTGCGCGTCAATCGCGCACTGGCGTTGTTTTTGGGAAT
TGTGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT236343 WP_000885424.1 NZ_CP092510:2390910-2391158 [Salmonella enterica subsp. enterica serovar Thompson]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT236343 NZ_LR536450:2017516-2017704 [Methylocella tundrae]
ATGGCGAGTTATCGCCAGAGGATGCGGGCGGCGGGTCTGCGCCCCGTGCAAATCTGGGCGCCGGACAGCCGCGCCCCCGA
TTTTGCCGAAAAATGCCGCGCTCAGGCGCGCGCCGTCGCCGCCAGCGATCCGGCTGGCGATGAGATCATGCGCTTTGTCG
CCAGCGTCTATGAATGGCCCGAGCCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References