Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 845449..846074 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name vapC Uniprot ID A0A5I5T1K0
Locus tag MKE90_RS04085 Protein ID WP_001748684.1
Coordinates 845676..846074 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag MKE90_RS04080 Protein ID WP_000557545.1
Coordinates 845449..845676 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS04050 (840462) 840462..841979 + 1518 WP_000003339.1 lysine--tRNA ligase -
MKE90_RS04055 (842055) 842055..842600 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
MKE90_RS04060 (842865) 842865..843623 + 759 WP_000244328.1 amidase activator ActS -
MKE90_RS04070 (843908) 843908..844714 - 807 WP_077907190.1 DUF1460 domain-containing protein -
MKE90_RS04075 (844989) 844989..845240 - 252 WP_001748683.1 hypothetical protein -
MKE90_RS04080 (845449) 845449..845676 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
MKE90_RS04085 (845676) 845676..846074 + 399 WP_001748684.1 tRNA(fMet)-specific endonuclease VapC Toxin
MKE90_RS04090 (846880) 846880..847416 + 537 WP_017465475.1 STM3031 family outer membrane protein -
MKE90_RS04095 (847463) 847463..848095 + 633 WP_000835265.1 YfdX family protein -
MKE90_RS04100 (848814) 848814..849401 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 843908..855219 11311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14995.39 Da        Isoelectric Point: 7.7780

>T236333 WP_001748684.1 NZ_CP092510:845676-846074 [Salmonella enterica subsp. enterica serovar Thompson]
MLKFMLDTNTCIFTIKNKPEHVKERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T236333 NZ_LR536431:2621396-2621680 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT236333 WP_000557545.1 NZ_CP092510:845449-845676 [Salmonella enterica subsp. enterica serovar Thompson]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT236333 NZ_LR536431:2621161-2621403 [Escherichia coli]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATTAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGTTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGTCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5T1K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References