Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834530..835190 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MKE90_RS04020 Protein ID WP_000244756.1
Coordinates 834777..835190 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MKE90_RS04015 Protein ID WP_000351186.1
Coordinates 834530..834796 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS03995 (830457) 830457..831890 - 1434 WP_017465472.1 6-phospho-beta-glucosidase BglA -
MKE90_RS04000 (832049) 832049..832360 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MKE90_RS04005 (832525) 832525..833184 + 660 WP_000250289.1 hemolysin III family protein -
MKE90_RS04010 (833300) 833300..834280 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MKE90_RS04015 (834530) 834530..834796 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MKE90_RS04020 (834777) 834777..835190 + 414 WP_000244756.1 protein YgfX Toxin
MKE90_RS04025 (835243) 835243..835764 - 522 WP_001055885.1 flavodoxin FldB -
MKE90_RS04030 (835877) 835877..836773 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MKE90_RS04035 (836797) 836797..837510 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKE90_RS04040 (837516) 837516..839249 + 1734 WP_017465473.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T236332 WP_000244756.1 NZ_CP092510:834777-835190 [Salmonella enterica subsp. enterica serovar Thompson]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T236332 NZ_LR536431:2165103-2165206 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT236332 WP_000351186.1 NZ_CP092510:834530-834796 [Salmonella enterica subsp. enterica serovar Thompson]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236332 NZ_LR536431:c2165244-2164973 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References